TY - JOUR
T1 - Framboidal Nanoparticles Containing a Curcumin-Phenylboronic Acid Complex with Antiangiogenic and Anticancer Activities
AU - Van Der Vlies, André J.
AU - Morisaki, Manami
AU - Neng, Hoi I.
AU - Hansen, Emma M.
AU - Hasegawa, Urara
N1 - Funding Information:
We thank Dr. Kazunari Akiyoshi (Kyoto University, Japan) for help with TEM experiments. This work was supported by a Research Grant from the Ogasawara Foundation for the Promotion of Science and Engineering, Japan.
PY - 2019/3/20
Y1 - 2019/3/20
N2 - Curcumin (Cur) has a wide range of bioactivities that show potential for the treatment of cancer as well as chronic diseases associated with inflammation and aging. However, the therapeutic efficacy of Cur has been hampered by its rapid degradation under physiological conditions and low aqueous solubility. To address these problems, we prepared Cur-loaded polymeric nanoparticles (CNPs), in which Cur was complexed with phenylboronic acid-containing framboidal nanoparticles (NPs), by simple mixing of Cur and NPs in an aqueous solution. CNPs showed improved chemical stability of Cur and released it in a sustained manner under physiological conditions. Furthermore, CNPs significantly enhanced the antiangiogenic and anticancer activities of Cur in chicken chorioallantoic membrane models.
AB - Curcumin (Cur) has a wide range of bioactivities that show potential for the treatment of cancer as well as chronic diseases associated with inflammation and aging. However, the therapeutic efficacy of Cur has been hampered by its rapid degradation under physiological conditions and low aqueous solubility. To address these problems, we prepared Cur-loaded polymeric nanoparticles (CNPs), in which Cur was complexed with phenylboronic acid-containing framboidal nanoparticles (NPs), by simple mixing of Cur and NPs in an aqueous solution. CNPs showed improved chemical stability of Cur and released it in a sustained manner under physiological conditions. Furthermore, CNPs significantly enhanced the antiangiogenic and anticancer activities of Cur in chicken chorioallantoic membrane models.
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U2 - 10.1021/acs.bioconjchem.9b00006
DO - 10.1021/acs.bioconjchem.9b00006
M3 - Article
C2 - 30676733
AN - SCOPUS:85063163331
VL - 30
SP - 861
EP - 870
JO - Bioconjugate Chemistry
JF - Bioconjugate Chemistry
SN - 1043-1802
IS - 3
ER -