Free water improves detection of changes in the substantia nigra in parkinsonism

A multisite study

Edward Ofori, Florian Krismer, Roxana G. Burciu, Ofer Pasternak, Johanna L. McCracken, Mechelle Lewis, Guangwei Du, Nikolaus R. McFarland, Michael S. Okun, Werner Poewe, Christoph Mueller, Elke R. Gizewski, Michael Schocke, Christian Kremser, Hong Li, Xuemei Huang, Klaus Seppi, David E. Vaillancourt

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. Methods: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra. Correlations were computed between diffusion MRI measures and clinical measures. Results: In the posterior substantia nigra, free water was greater for PSP than MSA and PD patients and controls. PD and MSA both had greater free water than controls. Free-water-corrected fractional anisotropy values were greater for PSP patents than for controls and PD patients. PSP and MSA patient single-tensor mean diffusivity values were greater than controls, and single-tensor fractional anisotropy values were lower for PSP patients than for healthy controls. The parkinsonism effect size for free water was 0.145 in the posterior substantia nigra and 0.072 for single-tensor mean diffusivity. The direction of correlations between single-tensor mean diffusivity and free-water values and clinical scores was similar at each site. Conclusions: Free-water values in the posterior substantia nigra provide a consistent pattern of findings across patients with PD, MSA, and PSP in a large cohort across 3 sites. Free water in the posterior substantia nigra relates to clinical measures of motor and cognitive symptoms in a large cohort of parkinsonism.

Original languageEnglish (US)
Pages (from-to)1457-1464
Number of pages8
JournalMovement Disorders
Volume32
Issue number10
DOIs
StatePublished - Oct 1 2017

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Parkinsonian Disorders
Substantia Nigra
Water
Anisotropy
Diffusion Magnetic Resonance Imaging
Neurobehavioral Manifestations
Patents
Movement Disorders
Primary Spontaneous Pneumothorax
Cohort Studies
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Ofori, E., Krismer, F., Burciu, R. G., Pasternak, O., McCracken, J. L., Lewis, M., ... Vaillancourt, D. E. (2017). Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study. Movement Disorders, 32(10), 1457-1464. https://doi.org/10.1002/mds.27100
Ofori, Edward ; Krismer, Florian ; Burciu, Roxana G. ; Pasternak, Ofer ; McCracken, Johanna L. ; Lewis, Mechelle ; Du, Guangwei ; McFarland, Nikolaus R. ; Okun, Michael S. ; Poewe, Werner ; Mueller, Christoph ; Gizewski, Elke R. ; Schocke, Michael ; Kremser, Christian ; Li, Hong ; Huang, Xuemei ; Seppi, Klaus ; Vaillancourt, David E. / Free water improves detection of changes in the substantia nigra in parkinsonism : A multisite study. In: Movement Disorders. 2017 ; Vol. 32, No. 10. pp. 1457-1464.
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title = "Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study",
abstract = "Background: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. Methods: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra. Correlations were computed between diffusion MRI measures and clinical measures. Results: In the posterior substantia nigra, free water was greater for PSP than MSA and PD patients and controls. PD and MSA both had greater free water than controls. Free-water-corrected fractional anisotropy values were greater for PSP patents than for controls and PD patients. PSP and MSA patient single-tensor mean diffusivity values were greater than controls, and single-tensor fractional anisotropy values were lower for PSP patients than for healthy controls. The parkinsonism effect size for free water was 0.145 in the posterior substantia nigra and 0.072 for single-tensor mean diffusivity. The direction of correlations between single-tensor mean diffusivity and free-water values and clinical scores was similar at each site. Conclusions: Free-water values in the posterior substantia nigra provide a consistent pattern of findings across patients with PD, MSA, and PSP in a large cohort across 3 sites. Free water in the posterior substantia nigra relates to clinical measures of motor and cognitive symptoms in a large cohort of parkinsonism.",
author = "Edward Ofori and Florian Krismer and Burciu, {Roxana G.} and Ofer Pasternak and McCracken, {Johanna L.} and Mechelle Lewis and Guangwei Du and McFarland, {Nikolaus R.} and Okun, {Michael S.} and Werner Poewe and Christoph Mueller and Gizewski, {Elke R.} and Michael Schocke and Christian Kremser and Hong Li and Xuemei Huang and Klaus Seppi and Vaillancourt, {David E.}",
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Ofori, E, Krismer, F, Burciu, RG, Pasternak, O, McCracken, JL, Lewis, M, Du, G, McFarland, NR, Okun, MS, Poewe, W, Mueller, C, Gizewski, ER, Schocke, M, Kremser, C, Li, H, Huang, X, Seppi, K & Vaillancourt, DE 2017, 'Free water improves detection of changes in the substantia nigra in parkinsonism: A multisite study', Movement Disorders, vol. 32, no. 10, pp. 1457-1464. https://doi.org/10.1002/mds.27100

Free water improves detection of changes in the substantia nigra in parkinsonism : A multisite study. / Ofori, Edward; Krismer, Florian; Burciu, Roxana G.; Pasternak, Ofer; McCracken, Johanna L.; Lewis, Mechelle; Du, Guangwei; McFarland, Nikolaus R.; Okun, Michael S.; Poewe, Werner; Mueller, Christoph; Gizewski, Elke R.; Schocke, Michael; Kremser, Christian; Li, Hong; Huang, Xuemei; Seppi, Klaus; Vaillancourt, David E.

In: Movement Disorders, Vol. 32, No. 10, 01.10.2017, p. 1457-1464.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Free water improves detection of changes in the substantia nigra in parkinsonism

T2 - A multisite study

AU - Ofori, Edward

AU - Krismer, Florian

AU - Burciu, Roxana G.

AU - Pasternak, Ofer

AU - McCracken, Johanna L.

AU - Lewis, Mechelle

AU - Du, Guangwei

AU - McFarland, Nikolaus R.

AU - Okun, Michael S.

AU - Poewe, Werner

AU - Mueller, Christoph

AU - Gizewski, Elke R.

AU - Schocke, Michael

AU - Kremser, Christian

AU - Li, Hong

AU - Huang, Xuemei

AU - Seppi, Klaus

AU - Vaillancourt, David E.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. Methods: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra. Correlations were computed between diffusion MRI measures and clinical measures. Results: In the posterior substantia nigra, free water was greater for PSP than MSA and PD patients and controls. PD and MSA both had greater free water than controls. Free-water-corrected fractional anisotropy values were greater for PSP patents than for controls and PD patients. PSP and MSA patient single-tensor mean diffusivity values were greater than controls, and single-tensor fractional anisotropy values were lower for PSP patients than for healthy controls. The parkinsonism effect size for free water was 0.145 in the posterior substantia nigra and 0.072 for single-tensor mean diffusivity. The direction of correlations between single-tensor mean diffusivity and free-water values and clinical scores was similar at each site. Conclusions: Free-water values in the posterior substantia nigra provide a consistent pattern of findings across patients with PD, MSA, and PSP in a large cohort across 3 sites. Free water in the posterior substantia nigra relates to clinical measures of motor and cognitive symptoms in a large cohort of parkinsonism.

AB - Background: Imaging markers that are sensitive to parkinsonism across multiple sites are critically needed for clinical trials. The objective of this study was to evaluate changes in the substantia nigra using single- and bi-tensor models of diffusion magnetic resonance imaging in PD, MSA, and PSP. Methods: The study cohort (n = 425) included 107 healthy controls and 184 PD, 63 MSA, and 71 PSP patients from 3 movement disorder centers. Bi-tensor free water, free-water-corrected fractional anisotropy, free-water-corrected mean diffusivity, single-tensor fractional anisotropy, and single-tensor mean diffusivity were computed for the anterior and posterior substantia nigra. Correlations were computed between diffusion MRI measures and clinical measures. Results: In the posterior substantia nigra, free water was greater for PSP than MSA and PD patients and controls. PD and MSA both had greater free water than controls. Free-water-corrected fractional anisotropy values were greater for PSP patents than for controls and PD patients. PSP and MSA patient single-tensor mean diffusivity values were greater than controls, and single-tensor fractional anisotropy values were lower for PSP patients than for healthy controls. The parkinsonism effect size for free water was 0.145 in the posterior substantia nigra and 0.072 for single-tensor mean diffusivity. The direction of correlations between single-tensor mean diffusivity and free-water values and clinical scores was similar at each site. Conclusions: Free-water values in the posterior substantia nigra provide a consistent pattern of findings across patients with PD, MSA, and PSP in a large cohort across 3 sites. Free water in the posterior substantia nigra relates to clinical measures of motor and cognitive symptoms in a large cohort of parkinsonism.

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U2 - 10.1002/mds.27100

DO - 10.1002/mds.27100

M3 - Article

VL - 32

SP - 1457

EP - 1464

JO - Movement Disorders

JF - Movement Disorders

SN - 0885-3185

IS - 10

ER -