Frequent Spread of Plasmodium vivax Malaria Maintains High Genetic Diversity at the Myanmar-China Border, Without Distance and Landscape Barriers

Eugenia Lo, Nancy Lam, Elizabeth Hemming-Schroeder, Jennifer Nguyen, Guofa Zhou, Ming Chieh Lee, Zhaoqing Yang, Liwang Cui, Guiyun Yan

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background: In Myanmar, civil unrest and the establishment of internally displaced person (IDP) settlements along the Myanmar-China border have impacted malaria transmission.

Methods: Microsatellite markers were used to examine source-sink dynamics for Plasmodium vivax between IDP settlements and surrounding villages in the border region. Genotypic structure and diversity were compared across the 3 years following the establishment of IDP settlements, to infer demographic history. We investigated whether human migration and landscape heterogeneity contributed to P. vivax transmission.

Results: P. vivax from IDP settlements and local communities consistently exhibited high genetic diversity within populations but low polyclonality within individuals. No apparent genetic structure was observed among populations and years. P. vivax genotypes in China were similar to those in Myanmar, and parasite introduction was unidirectional. Landscape factors, including distance, elevation, and land cover, do not appear to impede parasite gene flow.

Conclusions: The admixture of P. vivax genotypes suggested that parasite gene flow via human movement contributes to the spread of malaria both locally in Myanmar and across the international border. Our genetic findings highlight the presence of large P. vivax gene reservoirs that can sustain transmission. Thus, it is important to reinforce and improve existing control efforts along border areas.

Original languageEnglish (US)
Pages (from-to)1254-1263
Number of pages10
JournalThe Journal of infectious diseases
Volume216
Issue number10
DOIs
StatePublished - Dec 5 2017

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Myanmar
Vivax Malaria
Plasmodium vivax
China
Parasites
Gene Flow
Malaria
Human Migration
Genotype
Genetic Structures
Microsatellite Repeats
Population
Demography
Genes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Lo, Eugenia ; Lam, Nancy ; Hemming-Schroeder, Elizabeth ; Nguyen, Jennifer ; Zhou, Guofa ; Lee, Ming Chieh ; Yang, Zhaoqing ; Cui, Liwang ; Yan, Guiyun. / Frequent Spread of Plasmodium vivax Malaria Maintains High Genetic Diversity at the Myanmar-China Border, Without Distance and Landscape Barriers. In: The Journal of infectious diseases. 2017 ; Vol. 216, No. 10. pp. 1254-1263.
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Frequent Spread of Plasmodium vivax Malaria Maintains High Genetic Diversity at the Myanmar-China Border, Without Distance and Landscape Barriers. / Lo, Eugenia; Lam, Nancy; Hemming-Schroeder, Elizabeth; Nguyen, Jennifer; Zhou, Guofa; Lee, Ming Chieh; Yang, Zhaoqing; Cui, Liwang; Yan, Guiyun.

In: The Journal of infectious diseases, Vol. 216, No. 10, 05.12.2017, p. 1254-1263.

Research output: Contribution to journalArticle

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AU - Zhou, Guofa

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AU - Yang, Zhaoqing

AU - Cui, Liwang

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N2 - Background: In Myanmar, civil unrest and the establishment of internally displaced person (IDP) settlements along the Myanmar-China border have impacted malaria transmission.Methods: Microsatellite markers were used to examine source-sink dynamics for Plasmodium vivax between IDP settlements and surrounding villages in the border region. Genotypic structure and diversity were compared across the 3 years following the establishment of IDP settlements, to infer demographic history. We investigated whether human migration and landscape heterogeneity contributed to P. vivax transmission.Results: P. vivax from IDP settlements and local communities consistently exhibited high genetic diversity within populations but low polyclonality within individuals. No apparent genetic structure was observed among populations and years. P. vivax genotypes in China were similar to those in Myanmar, and parasite introduction was unidirectional. Landscape factors, including distance, elevation, and land cover, do not appear to impede parasite gene flow.Conclusions: The admixture of P. vivax genotypes suggested that parasite gene flow via human movement contributes to the spread of malaria both locally in Myanmar and across the international border. Our genetic findings highlight the presence of large P. vivax gene reservoirs that can sustain transmission. Thus, it is important to reinforce and improve existing control efforts along border areas.

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