From cancer immunoediting to new strategies in cancer immunotherapy: The roles of immune cells and mechanics in oncology

Virginia Aragon-Sanabria, Gloria B. Kim, Cheng Dong

Research output: Chapter in Book/Report/Conference proceedingChapter

5 Scopus citations

Abstract

For the last three decades, the concept of immunoediting has evolved to characterize our increasing understanding of the interactions between cells from the immune system and cancer development. Elucidating the role of immune cells in the progression of cancer has been very challenging due to their dual role; the immune system can either suppress tumor formation by killing cancer cells, or it can also promote tumor growth. Revealing how immune cells are hampered by the tumor microenvironment and how they aid tumor progression has signaled strategies to reverse these effects and control cancer cell growth; this has been the advent of immunotherapy design. More recently, the role of physical forces in the process of immunoediting has been highlighted by multiple studies focusing on understanding how force changes in the stiffness of the extracellular matrix and fluid flow shear stress contribute to tumor development. Using models in vitro that incorporate biomechanical components, it has been shown that these physical aspects are not only important during the formation and growth of primary tumors, but in the metastatic process as well. In this way, we have also gained insight into the interactions occurring within the vascular system, which are highly affected by the dynamics of physical collisions between cells and by shear forces. Here, we review the concept of cancer immunoediting with an emphasis on biomechanics and conclude with a summary on current immunotherapies and potential new strategies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages113-138
Number of pages26
DOIs
StatePublished - Jan 1 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1092
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Aragon-Sanabria, V., Kim, G. B., & Dong, C. (2018). From cancer immunoediting to new strategies in cancer immunotherapy: The roles of immune cells and mechanics in oncology. In Advances in Experimental Medicine and Biology (pp. 113-138). (Advances in Experimental Medicine and Biology; Vol. 1092). Springer New York LLC. https://doi.org/10.1007/978-3-319-95294-9_7