TY - JOUR
T1 - Frontolimbic functioning during threat-related attention
T2 - Relations to early behavioral inhibition and anxiety in children
AU - Fu, Xiaoxue
AU - Taber-Thomas, Bradley C.
AU - Pérez-Edgar, Koraly
N1 - Funding Information:
This work is supported by a grant from the National Institutes of Health [BRAINS R01 MH094633] to KPE. The authors would like to thank the Penn State Social, Life, & Engineering Sciences Imaging Center (SLEIC) 3T MRI Facility, the TAU / NIMH ABMT Initiative for providing the toolkit, and ?the many individuals who contributed to the data collection and data processing. We would especially like to thank the parents of the children who participated and continue to participate in our studies.
Publisher Copyright:
© 2015 Elsevier B.V.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Children with behavioral inhibition (BI), a temperament characterized by biologically-based hyper-vigilance to novelty, display threat-related attention biases (AB) that shape developmental trajectories of risk for anxiety. Here we explore the relations between BI, neural function, and anxiety. Fifty-six 9–12-year-olds (23 behaviorally inhibited) performed the dot-probe task while undergoing fMRI. AB scores were not associated with BI group or parent-rated anxiety symptoms. Trials requiring attention orienting away from threat engaged an executive and threat-attention network (dlPFC, vlPFC, mPFC, and amygdala). Within that network, behaviorally inhibited children showed greater activation in the right dlPFC. Heightened dlPFC activation related to increased anxiety, and BI levels accounted for the direct relation between dlPFC activation and anxiety. Behaviorally inhibited children may engage the executive attention system during threat-related processing as a compensatory mechanism. We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety.
AB - Children with behavioral inhibition (BI), a temperament characterized by biologically-based hyper-vigilance to novelty, display threat-related attention biases (AB) that shape developmental trajectories of risk for anxiety. Here we explore the relations between BI, neural function, and anxiety. Fifty-six 9–12-year-olds (23 behaviorally inhibited) performed the dot-probe task while undergoing fMRI. AB scores were not associated with BI group or parent-rated anxiety symptoms. Trials requiring attention orienting away from threat engaged an executive and threat-attention network (dlPFC, vlPFC, mPFC, and amygdala). Within that network, behaviorally inhibited children showed greater activation in the right dlPFC. Heightened dlPFC activation related to increased anxiety, and BI levels accounted for the direct relation between dlPFC activation and anxiety. Behaviorally inhibited children may engage the executive attention system during threat-related processing as a compensatory mechanism. We provide preliminary evidence that the link between PFC functioning and anxiety might be attributed to early-emerging temperamental vulnerabilities present before the emergence of clinical anxiety.
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U2 - 10.1016/j.biopsycho.2015.08.010
DO - 10.1016/j.biopsycho.2015.08.010
M3 - Article
C2 - 26325222
AN - SCOPUS:84940829812
VL - 122
SP - 98
EP - 109
JO - Biological Psychology
JF - Biological Psychology
SN - 0019-493X
ER -