Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age

David J. Madden, Emily L. Parks, Catherine W. Tallman, Maria A. Boylan, David A. Hoagey, Sally B. Cocjin, Micah A. Johnson, Ying Hui Chou, Guy G. Potter, Nan Kuei Chen, Lauren E. Packard, Rachel E. Siciliano, Zachary A. Monge, Michele T. Diaz

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional guidance (featural salience). Participants were 68 healthy adults, distributed continuously across 19 to 78 years of age. Frontoparietal regions of interest (ROIs) were defined from resting-state scans obtained prior to task-related fMRI. The search target was defined by a conjunction of color and orientation. Each display contained one item that was larger than the others (i.e., a size singleton) but was not informative regarding target identity. Analyses of search reaction time (RT) indicated that bottom-up attentional guidance from the size singleton (when coincident with the target) was relatively constant as a function of age. Frontoparietal fMRI activation related to target detection was constant as a function of age, as was the reduction in activation associated with salient targets. However, for individuals 35 years of age and older, engagement of the left frontal eye field (FEF) in bottom-up guidance was more prominent than for younger individuals. Further, the agerelated differences in left FEF activation were a consequence of decreasing resting-state functional connectivity in visual sensory regions. These findings indicate that age-related compensatory effects may be expressed in the relation between activation and behavior, rather than in the magnitude of activation, and that relevant changes in the activation-RT relation may begin at a relatively early point in adulthood.

Original languageEnglish (US)
Pages (from-to)2128-2149
Number of pages22
JournalHuman Brain Mapping
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2017

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Magnetic Resonance Imaging
Frontal Lobe
Color

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Madden, D. J., Parks, E. L., Tallman, C. W., Boylan, M. A., Hoagey, D. A., Cocjin, S. B., ... Diaz, M. T. (2017). Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age. Human Brain Mapping, 38(4), 2128-2149. https://doi.org/10.1002/hbm.23509
Madden, David J. ; Parks, Emily L. ; Tallman, Catherine W. ; Boylan, Maria A. ; Hoagey, David A. ; Cocjin, Sally B. ; Johnson, Micah A. ; Chou, Ying Hui ; Potter, Guy G. ; Chen, Nan Kuei ; Packard, Lauren E. ; Siciliano, Rachel E. ; Monge, Zachary A. ; Diaz, Michele T. / Frontoparietal activation during visual conjunction search : Effects of bottom-up guidance and adult age. In: Human Brain Mapping. 2017 ; Vol. 38, No. 4. pp. 2128-2149.
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Madden, DJ, Parks, EL, Tallman, CW, Boylan, MA, Hoagey, DA, Cocjin, SB, Johnson, MA, Chou, YH, Potter, GG, Chen, NK, Packard, LE, Siciliano, RE, Monge, ZA & Diaz, MT 2017, 'Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age', Human Brain Mapping, vol. 38, no. 4, pp. 2128-2149. https://doi.org/10.1002/hbm.23509

Frontoparietal activation during visual conjunction search : Effects of bottom-up guidance and adult age. / Madden, David J.; Parks, Emily L.; Tallman, Catherine W.; Boylan, Maria A.; Hoagey, David A.; Cocjin, Sally B.; Johnson, Micah A.; Chou, Ying Hui; Potter, Guy G.; Chen, Nan Kuei; Packard, Lauren E.; Siciliano, Rachel E.; Monge, Zachary A.; Diaz, Michele T.

In: Human Brain Mapping, Vol. 38, No. 4, 01.04.2017, p. 2128-2149.

Research output: Contribution to journalArticle

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T2 - Effects of bottom-up guidance and adult age

AU - Madden, David J.

AU - Parks, Emily L.

AU - Tallman, Catherine W.

AU - Boylan, Maria A.

AU - Hoagey, David A.

AU - Cocjin, Sally B.

AU - Johnson, Micah A.

AU - Chou, Ying Hui

AU - Potter, Guy G.

AU - Chen, Nan Kuei

AU - Packard, Lauren E.

AU - Siciliano, Rachel E.

AU - Monge, Zachary A.

AU - Diaz, Michele T.

PY - 2017/4/1

Y1 - 2017/4/1

N2 - We conducted functional magnetic resonance imaging (fMRI) with a visual search paradigm to test the hypothesis that aging is associated with increased frontoparietal involvement in both target detection and bottom-up attentional guidance (featural salience). Participants were 68 healthy adults, distributed continuously across 19 to 78 years of age. Frontoparietal regions of interest (ROIs) were defined from resting-state scans obtained prior to task-related fMRI. The search target was defined by a conjunction of color and orientation. Each display contained one item that was larger than the others (i.e., a size singleton) but was not informative regarding target identity. Analyses of search reaction time (RT) indicated that bottom-up attentional guidance from the size singleton (when coincident with the target) was relatively constant as a function of age. Frontoparietal fMRI activation related to target detection was constant as a function of age, as was the reduction in activation associated with salient targets. However, for individuals 35 years of age and older, engagement of the left frontal eye field (FEF) in bottom-up guidance was more prominent than for younger individuals. Further, the agerelated differences in left FEF activation were a consequence of decreasing resting-state functional connectivity in visual sensory regions. These findings indicate that age-related compensatory effects may be expressed in the relation between activation and behavior, rather than in the magnitude of activation, and that relevant changes in the activation-RT relation may begin at a relatively early point in adulthood.

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Madden DJ, Parks EL, Tallman CW, Boylan MA, Hoagey DA, Cocjin SB et al. Frontoparietal activation during visual conjunction search: Effects of bottom-up guidance and adult age. Human Brain Mapping. 2017 Apr 1;38(4):2128-2149. https://doi.org/10.1002/hbm.23509