Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose

Bennett J. Giardina, Hui Ling Chiang

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Abstract

Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.

Original languageEnglish (US)
Article numbere27216
JournalCommunicative and Integrative Biology
Volume6
Issue number6
DOIs
Publication statusPublished - Dec 1 2013

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All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

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