TY - JOUR
T1 - Fructose-1,6-bisphosphatase, malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin a are secreted in Saccharomyces cerevisiae grown in low glucose
AU - Giardina, Bennett J.
AU - Chiang, Hui Ling
N1 - Funding Information:
Immuno-TEM was performed using the EM Core Facility at Penn State College of Medicine. This work was supported by Penn State Bridge Fund to Hui-Ling Chiang.
PY - 2013
Y1 - 2013
N2 - Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.
AB - Our previous studies demonstrated that the key gluconeogenic enzyme fructose-1,6-bisphosphatase is secreted when Saccharomyces cerevisiae are starved of glucose for a prolonged period of time. In this study, we showed that malate dehydrogenase, isocitrate lyase, phosphoenolpyruvate carboxykinase, glyceraldehyde-3-phosphate dehydrogenase, and cyclophilin A are also secreted in glucose-starved cells. Thus, both gluconeogenic and nongluconeogenic enzymes are secreted via the non-classical pathway.
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U2 - 10.4161/cib.27216
DO - 10.4161/cib.27216
M3 - Article
C2 - 24563717
AN - SCOPUS:84894031918
SN - 1942-0889
VL - 6
JO - Communicative and Integrative Biology
JF - Communicative and Integrative Biology
IS - 6
M1 - e27216
ER -