Functional alignment with anatomical networks is associated with cognitive flexibility

John D. Medaglia, Weiyu Huang, Elisabeth A. Karuza, Apoorva Kelkar, Sharon L. Thompson-Schill, Alejandro Ribeiro, Danielle S. Bassett

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.

Original languageEnglish (US)
Pages (from-to)156-164
Number of pages9
JournalNature Human Behaviour
Volume2
Issue number2
DOIs
StatePublished - Feb 1 2018

Fingerprint

Aptitude
Brain
Neuroimaging
Oxygen
White Matter

All Science Journal Classification (ASJC) codes

  • Social Psychology
  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Medaglia, J. D., Huang, W., Karuza, E. A., Kelkar, A., Thompson-Schill, S. L., Ribeiro, A., & Bassett, D. S. (2018). Functional alignment with anatomical networks is associated with cognitive flexibility. Nature Human Behaviour, 2(2), 156-164. https://doi.org/10.1038/s41562-017-0260-9
Medaglia, John D. ; Huang, Weiyu ; Karuza, Elisabeth A. ; Kelkar, Apoorva ; Thompson-Schill, Sharon L. ; Ribeiro, Alejandro ; Bassett, Danielle S. / Functional alignment with anatomical networks is associated with cognitive flexibility. In: Nature Human Behaviour. 2018 ; Vol. 2, No. 2. pp. 156-164.
@article{122b3e0d0dd343f2a6022b01990f2fb7,
title = "Functional alignment with anatomical networks is associated with cognitive flexibility",
abstract = "Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.",
author = "Medaglia, {John D.} and Weiyu Huang and Karuza, {Elisabeth A.} and Apoorva Kelkar and Thompson-Schill, {Sharon L.} and Alejandro Ribeiro and Bassett, {Danielle S.}",
year = "2018",
month = "2",
day = "1",
doi = "10.1038/s41562-017-0260-9",
language = "English (US)",
volume = "2",
pages = "156--164",
journal = "Nature Human Behaviour",
issn = "2397-3374",
publisher = "Nature Publishing Group",
number = "2",

}

Medaglia, JD, Huang, W, Karuza, EA, Kelkar, A, Thompson-Schill, SL, Ribeiro, A & Bassett, DS 2018, 'Functional alignment with anatomical networks is associated with cognitive flexibility', Nature Human Behaviour, vol. 2, no. 2, pp. 156-164. https://doi.org/10.1038/s41562-017-0260-9

Functional alignment with anatomical networks is associated with cognitive flexibility. / Medaglia, John D.; Huang, Weiyu; Karuza, Elisabeth A.; Kelkar, Apoorva; Thompson-Schill, Sharon L.; Ribeiro, Alejandro; Bassett, Danielle S.

In: Nature Human Behaviour, Vol. 2, No. 2, 01.02.2018, p. 156-164.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functional alignment with anatomical networks is associated with cognitive flexibility

AU - Medaglia, John D.

AU - Huang, Weiyu

AU - Karuza, Elisabeth A.

AU - Kelkar, Apoorva

AU - Thompson-Schill, Sharon L.

AU - Ribeiro, Alejandro

AU - Bassett, Danielle S.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.

AB - Cognitive flexibility describes the human ability to switch between modes of mental function to achieve goals. Mental switching is accompanied by transient changes in brain activity, which must occur atop an anatomical architecture that bridges disparate cortical and subcortical regions via underlying white matter tracts. However, an integrated understanding of how white matter networks might constrain brain dynamics during cognitive processes requiring flexibility has remained elusive. Here, to address this challenge, we applied emerging tools from graph signal processing to examine whether blood oxygen level-dependent signals measured at each point in time correspond to complex underlying anatomical networks in 28 individuals performing a perceptual task that probed cognitive flexibility. We found that the alignment between functional signals and the architecture of the underlying white matter network was associated with greater cognitive flexibility across subjects. By computing a concise measure using multi-modal neuroimaging data, we uncovered an integrated structure-function relation of human behaviour.

UR - http://www.scopus.com/inward/record.url?scp=85042753812&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042753812&partnerID=8YFLogxK

U2 - 10.1038/s41562-017-0260-9

DO - 10.1038/s41562-017-0260-9

M3 - Article

C2 - 30498789

AN - SCOPUS:85042753812

VL - 2

SP - 156

EP - 164

JO - Nature Human Behaviour

JF - Nature Human Behaviour

SN - 2397-3374

IS - 2

ER -