Functional and Cardiovascular Measurements in Patients with Peripheral Artery Disease: COMPARISON between MEN and WOMEN

Marilia A. Correia, Adilson Santos Andrade De Sousa, Aluísio Andrade-Lima, Antônio H. Germano-Soares, Antônio Eduardo Zerati, Pedro Puech-Leao, Nelson Wolosker, Andrew W. Gardner, Raphael M. Ritti-Dias, Gabriel G. Cucato

Research output: Contribution to journalArticle

Abstract

Purpose: To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD). Methods: This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability. Results: Women had lower claudication onset distance (P =.033) and 6MWT distance (P <.001), and similar percentage of the predicted 6MWT distance (P >.05). Women had higher pulse pressure (P =.002), augmentation index (P <.001), augmentation index corrected by 75 bpm (P <.001), and brachial and central systolic blood pressure (P =.041 and P =.029). Diastolic blood pressure, pulse wave velocity, and heart rate variability were similar between sexes (P >.05). Conclusion: Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD.

Original languageEnglish (US)
JournalJournal of Cardiopulmonary Rehabilitation and Prevention
DOIs
StateAccepted/In press - Jan 1 2019

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Peripheral Arterial Disease
Blood Pressure
Vascular Stiffness
Cross-Sectional Studies
Heart Rate
Hypertension
Walk Test

All Science Journal Classification (ASJC) codes

  • Rehabilitation
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Correia, M. A., De Sousa, A. S. A., Andrade-Lima, A., Germano-Soares, A. H., Zerati, A. E., Puech-Leao, P., ... Cucato, G. G. (Accepted/In press). Functional and Cardiovascular Measurements in Patients with Peripheral Artery Disease: COMPARISON between MEN and WOMEN. Journal of Cardiopulmonary Rehabilitation and Prevention. https://doi.org/10.1097/HCR.0000000000000437
Correia, Marilia A. ; De Sousa, Adilson Santos Andrade ; Andrade-Lima, Aluísio ; Germano-Soares, Antônio H. ; Zerati, Antônio Eduardo ; Puech-Leao, Pedro ; Wolosker, Nelson ; Gardner, Andrew W. ; Ritti-Dias, Raphael M. ; Cucato, Gabriel G. / Functional and Cardiovascular Measurements in Patients with Peripheral Artery Disease : COMPARISON between MEN and WOMEN. In: Journal of Cardiopulmonary Rehabilitation and Prevention. 2019.
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Functional and Cardiovascular Measurements in Patients with Peripheral Artery Disease : COMPARISON between MEN and WOMEN. / Correia, Marilia A.; De Sousa, Adilson Santos Andrade; Andrade-Lima, Aluísio; Germano-Soares, Antônio H.; Zerati, Antônio Eduardo; Puech-Leao, Pedro; Wolosker, Nelson; Gardner, Andrew W.; Ritti-Dias, Raphael M.; Cucato, Gabriel G.

In: Journal of Cardiopulmonary Rehabilitation and Prevention, 01.01.2019.

Research output: Contribution to journalArticle

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T1 - Functional and Cardiovascular Measurements in Patients with Peripheral Artery Disease

T2 - COMPARISON between MEN and WOMEN

AU - Correia, Marilia A.

AU - De Sousa, Adilson Santos Andrade

AU - Andrade-Lima, Aluísio

AU - Germano-Soares, Antônio H.

AU - Zerati, Antônio Eduardo

AU - Puech-Leao, Pedro

AU - Wolosker, Nelson

AU - Gardner, Andrew W.

AU - Ritti-Dias, Raphael M.

AU - Cucato, Gabriel G.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD). Methods: This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability. Results: Women had lower claudication onset distance (P =.033) and 6MWT distance (P <.001), and similar percentage of the predicted 6MWT distance (P >.05). Women had higher pulse pressure (P =.002), augmentation index (P <.001), augmentation index corrected by 75 bpm (P <.001), and brachial and central systolic blood pressure (P =.041 and P =.029). Diastolic blood pressure, pulse wave velocity, and heart rate variability were similar between sexes (P >.05). Conclusion: Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD.

AB - Purpose: To compare functional and cardiovascular variables of men and women with peripheral artery disease (PAD). Methods: This observational, cross-sectional study included 67 women and 144 men (age 66 ± 9 and 67 ± 10 yr, respectively) with PAD. Patients were submitted to a clinical evaluation, 6-min walk test (6MWT) and cardiovascular evaluation, including blood pressure, arterial stiffness variables, and heart rate variability. Results: Women had lower claudication onset distance (P =.033) and 6MWT distance (P <.001), and similar percentage of the predicted 6MWT distance (P >.05). Women had higher pulse pressure (P =.002), augmentation index (P <.001), augmentation index corrected by 75 bpm (P <.001), and brachial and central systolic blood pressure (P =.041 and P =.029). Diastolic blood pressure, pulse wave velocity, and heart rate variability were similar between sexes (P >.05). Conclusion: Although predicted 6MWT performance was similar between sexes, women had higher blood pressure and wave reflection variables compared with men. Interventions to reduce blood pressure and wave reflection should be emphasized in women with PAD.

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