Functional anogel as nucleic acid career

Shin Ichi Sawada, Hirohito Ayame, Urara Hasegawa, Kazunari Akiyoshi

Research output: Contribution to conferencePaperpeer-review

Abstract

We reported that hydrogel nanoparticles (nanogels) were formed by self-assembly of cholesterol group bearing pullulans (CHP). We synthesized various cationic groups bearing CHP. The cationic CHP formed monodisperse cationic nanogels (30-40 nm) in water. In this study, we investigated the characteristic of cationic nanogels-nucleic acid complexes. Furthermore, I investigated the interaction between cationic nanogels-nucleic acid complexes and cells. The results indicate that various cationic nanogels and nucleic acid were complexed and formed nanosize particles. The CHP nanogel which modified spermine acts as efficient nucleic acid carrier in cells.

Original languageEnglish (US)
Pages5463-5464
Number of pages2
StatePublished - 2006
Event55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan
Duration: Sep 20 2006Sep 22 2006

Conference

Conference55th Society of Polymer Science Japan Symposium on Macromolecules
CountryJapan
CityToyama
Period9/20/069/22/06

All Science Journal Classification (ASJC) codes

  • Engineering(all)

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