Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor

Kristina A. Neely, Ajay S. Kurani, Priyank Shukla, Peggy J. Planetta, Aparna Wagle Shukla, Jennifer G. Goldman, Daniel M. Corcos, Michael S. Okun, David E. Vaillancourt

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

It is well-established that during goal-directed motor tasks, patients with essential tremor have increased oscillations in the 0-3 and 3-8 Hz bands. It remains unclear if these increased oscillations relate to activity in specific brain regions. This study used task-based functional magnetic resonance imaging to compare the brain activity associated with oscillations in grip force output between patients with essential tremor, patients with Parkinson's disease who had clinically evident tremor, and healthy controls. The findings demonstrate that patients with essential tremor have increased brain activity in the motor cortex and supplementary motor area compared with controls, and this activity correlated positively with 3-8 Hz force oscillations. Brain activity in cerebellar lobules I-V was reduced in essential tremor compared with controls and correlated negatively with 0-3 Hz force oscillations. Widespread differences in brain activity were observed between essential tremor and Parkinson's disease. Using functional connectivity analyses during the task evidenced reduced cerebellar-cortical functional connectivity in patients with essential tremor compared with controls and Parkinson's disease. This study provides new evidence that in essential tremor 3-8 Hz force oscillations relate to hyperactivity in motor cortex, 0-3 Hz force oscillations relate to the hypoactivity in the cerebellum, and cerebellar-cortical functional connectivity is impaired.

Original languageEnglish (US)
Pages (from-to)4192-4202
Number of pages11
JournalCerebral Cortex
Volume25
Issue number11
DOIs
StatePublished - Jan 1 2015

Fingerprint

Essential Tremor
Brain
Motor Cortex
Parkinson Disease
Hand Strength
Tremor
Cerebellum
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Neely, K. A., Kurani, A. S., Shukla, P., Planetta, P. J., Shukla, A. W., Goldman, J. G., ... Vaillancourt, D. E. (2015). Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor. Cerebral Cortex, 25(11), 4192-4202. https://doi.org/10.1093/cercor/bhu142
Neely, Kristina A. ; Kurani, Ajay S. ; Shukla, Priyank ; Planetta, Peggy J. ; Shukla, Aparna Wagle ; Goldman, Jennifer G. ; Corcos, Daniel M. ; Okun, Michael S. ; Vaillancourt, David E. / Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor. In: Cerebral Cortex. 2015 ; Vol. 25, No. 11. pp. 4192-4202.
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Neely, KA, Kurani, AS, Shukla, P, Planetta, PJ, Shukla, AW, Goldman, JG, Corcos, DM, Okun, MS & Vaillancourt, DE 2015, 'Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor', Cerebral Cortex, vol. 25, no. 11, pp. 4192-4202. https://doi.org/10.1093/cercor/bhu142

Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor. / Neely, Kristina A.; Kurani, Ajay S.; Shukla, Priyank; Planetta, Peggy J.; Shukla, Aparna Wagle; Goldman, Jennifer G.; Corcos, Daniel M.; Okun, Michael S.; Vaillancourt, David E.

In: Cerebral Cortex, Vol. 25, No. 11, 01.01.2015, p. 4192-4202.

Research output: Contribution to journalArticle

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Neely KA, Kurani AS, Shukla P, Planetta PJ, Shukla AW, Goldman JG et al. Functional brain activity relates to 0-3 and 3-8 Hz force oscillations in essential tremor. Cerebral Cortex. 2015 Jan 1;25(11):4192-4202. https://doi.org/10.1093/cercor/bhu142