Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement

Abhijeet Joshi, Garland Fussell, Jonathan Thomas, Andrew Hsuan, Anthony Lowman, Andrew Karduna, Edward Vresilovic, Michele Marcolongo

Research output: Contribution to journalArticle

126 Citations (Scopus)

Abstract

Emerging techniques as an alternative to the current treatments of lower back pain include nucleus replacement by an artificial material, which aims to relieve pain and restore the normal spinal motion. The compressive mechanical behavior of the PVA/PVP hydrogel nucleus implant was assessed in the present study. PVA/PVP hydrogels were made with various PVP concentrations. The hydrogels were loaded statically under unconfined and confined conditions. Hydrogels were tested dynamically up to 10 million cycles for a compression fatigue. Also, hydrogel nucleus implants with a line-to-line fit, were implanted in the human cadaveric intervertebral discs (IVD) to determine the compressional behavior of the implanted discs. Hydrogel samples exhibited typical non-linear response under both unconfined and confined compressions. Properties of the confinement ring dictated the observed response. Hydrogel moduli and polymer content were not different pre- and post-fatigues. Slight geometrical changes (mostly recoverable) were observed post-fatigue. In cadavers, hydrogels restored the compressive stiffness of the denucleated disc when compared with equivalent condition of the IVD. The results of this study demonstrate that PVA/PVP hydrogels may be viable as nucleus pulposus implants. Further studies under complex loading conditions are warranted to better assess its potential as a replacement to the degenerated nucleus pulposus.

Original languageEnglish (US)
Pages (from-to)176-184
Number of pages9
JournalBiomaterials
Volume27
Issue number2
DOIs
StatePublished - Jan 1 2006

Fingerprint

Hydrogels
Mechanics
Hydrogel
Fatigue
Fatigue of materials
Intervertebral Disc
Low Back Pain
Cadaver
Polymers
Compaction
Stiffness
Nucleus Pulposus
Pain

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Joshi, A., Fussell, G., Thomas, J., Hsuan, A., Lowman, A., Karduna, A., ... Marcolongo, M. (2006). Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement. Biomaterials, 27(2), 176-184. https://doi.org/10.1016/j.biomaterials.2005.06.003
Joshi, Abhijeet ; Fussell, Garland ; Thomas, Jonathan ; Hsuan, Andrew ; Lowman, Anthony ; Karduna, Andrew ; Vresilovic, Edward ; Marcolongo, Michele. / Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement. In: Biomaterials. 2006 ; Vol. 27, No. 2. pp. 176-184.
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Joshi, A, Fussell, G, Thomas, J, Hsuan, A, Lowman, A, Karduna, A, Vresilovic, E & Marcolongo, M 2006, 'Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement', Biomaterials, vol. 27, no. 2, pp. 176-184. https://doi.org/10.1016/j.biomaterials.2005.06.003

Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement. / Joshi, Abhijeet; Fussell, Garland; Thomas, Jonathan; Hsuan, Andrew; Lowman, Anthony; Karduna, Andrew; Vresilovic, Edward; Marcolongo, Michele.

In: Biomaterials, Vol. 27, No. 2, 01.01.2006, p. 176-184.

Research output: Contribution to journalArticle

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Joshi A, Fussell G, Thomas J, Hsuan A, Lowman A, Karduna A et al. Functional compressive mechanics of a PVA/PVP nucleus pulposus replacement. Biomaterials. 2006 Jan 1;27(2):176-184. https://doi.org/10.1016/j.biomaterials.2005.06.003