Functional fingerprints of folds

Evidence for correlated structure-function evolution

Boris E. Shakhnovich, Nikolay Dokholyan, Charles DeLisi, Eugene I. Shakhnovich

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

Using structural similarity clustering of protein domains: protein domain universe graph (PDUG), and a hierarchical functional annotation: gene ontology (GO) as two evolutionary lenses, we find that each structural cluster (domain fold) exhibits a distribution of functions that is unique to it. These functional distributions are functional fingerprints that are specific to characteristic structural clusters and vary from cluster to cluster. Furthermore, as structural similarity threshold for domain clustering in the PDUG is relaxed we observe an influx of earlier-diverged domains into clusters. These domains join clusters without destroying the functional fingerprint. These results can be understood in light of a divergent evolution scenario that posits correlated divergence of structural and functional traits in protein domains from one or few progenitors.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalJournal of Molecular Biology
Volume326
Issue number1
DOIs
StatePublished - Feb 7 2003

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Dermatoglyphics
Cluster Analysis
Gene Ontology
Lenses
Protein Domains

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Cite this

Shakhnovich, Boris E. ; Dokholyan, Nikolay ; DeLisi, Charles ; Shakhnovich, Eugene I. / Functional fingerprints of folds : Evidence for correlated structure-function evolution. In: Journal of Molecular Biology. 2003 ; Vol. 326, No. 1. pp. 1-9.
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Functional fingerprints of folds : Evidence for correlated structure-function evolution. / Shakhnovich, Boris E.; Dokholyan, Nikolay; DeLisi, Charles; Shakhnovich, Eugene I.

In: Journal of Molecular Biology, Vol. 326, No. 1, 07.02.2003, p. 1-9.

Research output: Contribution to journalArticle

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