Functional gait analysis in a spinal contusion rat model

Abhiraj D. Bhimani, Pouyan Kheirkhah, Gregory Arnone, Cindy R. Nahhas, Prateek Kumar, Matt Wonais, Hugo Hidrogo, Eddy Aguilar, Daniel Spalinski, Mahie Gopalka, Steven Roth, Ankit I. Mehta

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Evaluating functional performance of spinal cord injury (SCI) rat models is essential for the development of novel treatments and breakthroughs. However, due to the variety of functional analysis methods available – each with its own strengths and weaknesses – it can be challenging to choose the most appropriate functional analysis test for the animal model. Therefore, we analyzed the strengths and weaknesses of five methods in order to determine which test is not only accurate and easily reproducible, but also relatively inexpensive so that it can be adopted universally. When comparing the Basso, Beattie, and Bresnahan (BBB) test, Ladder walking test, CatWalk test, Rotating Rod test, Microsoft Kinect system and VICON, we used the criteria of sensitivity, quality of data generated, statistical analysis of data, and rate of human error. These specific tests were chosen in order to compare the advantages and disadvantages of simple yet effective methods (BBB, Ladder test, and Rotating Rod test) to more complex and computerized methods (Catwalk, Microsoft Kinect and VICON).

Original languageEnglish (US)
Pages (from-to)540-546
Number of pages7
JournalNeuroscience and Biobehavioral Reviews
Volume83
DOIs
StatePublished - Dec 1 2017

Fingerprint

Contusions
Gait
Statistical Data Interpretation
Spinal Cord Injuries
Walking
Animal Models

All Science Journal Classification (ASJC) codes

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

Bhimani, A. D., Kheirkhah, P., Arnone, G., Nahhas, C. R., Kumar, P., Wonais, M., ... Mehta, A. I. (2017). Functional gait analysis in a spinal contusion rat model. Neuroscience and Biobehavioral Reviews, 83, 540-546. https://doi.org/10.1016/j.neubiorev.2017.09.007
Bhimani, Abhiraj D. ; Kheirkhah, Pouyan ; Arnone, Gregory ; Nahhas, Cindy R. ; Kumar, Prateek ; Wonais, Matt ; Hidrogo, Hugo ; Aguilar, Eddy ; Spalinski, Daniel ; Gopalka, Mahie ; Roth, Steven ; Mehta, Ankit I. / Functional gait analysis in a spinal contusion rat model. In: Neuroscience and Biobehavioral Reviews. 2017 ; Vol. 83. pp. 540-546.
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Bhimani, AD, Kheirkhah, P, Arnone, G, Nahhas, CR, Kumar, P, Wonais, M, Hidrogo, H, Aguilar, E, Spalinski, D, Gopalka, M, Roth, S & Mehta, AI 2017, 'Functional gait analysis in a spinal contusion rat model', Neuroscience and Biobehavioral Reviews, vol. 83, pp. 540-546. https://doi.org/10.1016/j.neubiorev.2017.09.007

Functional gait analysis in a spinal contusion rat model. / Bhimani, Abhiraj D.; Kheirkhah, Pouyan; Arnone, Gregory; Nahhas, Cindy R.; Kumar, Prateek; Wonais, Matt; Hidrogo, Hugo; Aguilar, Eddy; Spalinski, Daniel; Gopalka, Mahie; Roth, Steven; Mehta, Ankit I.

In: Neuroscience and Biobehavioral Reviews, Vol. 83, 01.12.2017, p. 540-546.

Research output: Contribution to journalReview article

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AU - Roth, Steven

AU - Mehta, Ankit I.

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