Functional implications of mitochondrial reactive oxygen species generated by oncogenic viruses

Young Bong Choi, Edward William Harhaj

Research output: Contribution to journalReview articlepeer-review

6 Scopus citations

Abstract

Between 15% and 20% of human cancers are associated with infection by oncogenic viruses. Oncogenic viruses, including HPV, HBV, HCV and HTLV-1, target mitochondria to influence cell proliferation and survival. Oncogenic viral gene products also trigger the production of reactive oxygen species which can elicit oxidative DNA damage and potentiate oncogenic host signaling pathways. Viral oncogenes may also subvert mitochondria quality control mechanisms such as mitophagy and metabolic adaptation pathways to promote virus replication. Here, we will review recent progress on viral regulation of mitophagy and metabolic adaptation and their roles in viral oncogenesis.

Original languageEnglish (US)
Pages (from-to)423-436
Number of pages14
JournalFrontiers in Biology
Volume9
Issue number6
DOIs
StatePublished - Dec 5 2014

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Ecology, Evolution, Behavior and Systematics
  • Ecology
  • Genetics

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