Functional mapping of developmental processes: Theory, applications, and prospects

Kiranmoy Das, Zhongwen Huang, Jingyuan Liu, Guifang Fu, Jiahan Li, Yao Li, Chunfa Tong, Junyi Gai, Rongling Wu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Functional mapping is a statistical tool for mapping quantitative trait loci (QTLs) that control the developmental pattern and process of a complex trait. Functional mapping has two significant advantages beyond traditional QTL mapping approaches. First, it integrates biological principles of trait formation into the model, enabling the biological interpretation of QTLs detected. Second, functional mapping is based on parsimonious modeling of mean-covariance structures, which enhances the statistical power of QTL detection. Here, we review the basic theory of functional mapping and describe one of its applications to plant genetics. We pinpoint several areas in which functional mapping can be integrated with systems biology to further our understanding of the genetic and genetic regulatory underpinnings of development.

Original languageEnglish (US)
Title of host publicationQuantitative Trait Loci (QTL)
Subtitle of host publicationMethods and Protocols
PublisherHumana Press Inc.
Pages227-243
Number of pages17
ISBN (Print)9781617797842
DOIs
StatePublished - 2012

Publication series

NameMethods in Molecular Biology
Volume871
ISSN (Print)1064-3745

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics

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