Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice

Rongling Wu, Chang Xing Ma, Wei Hou, Pablo Corva, Juan F. Medrano

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The high growth (hg) mutation increases body size in mice by 30-50%. Given the complexity of the genetic regulation of animal growth, it is likely that the effect of this major locus is mediated by other quantitative trait loci (QTL) with smaller effects within a web of gene interactions. In this article, we extend our functional mapping model to characterize modifier QTL that interact with the hg locus during ontogenetic growth. Our model is derived within the maximum-likelihood context, incorporated by mathematical aspects of growth laws and implemented with the EM algorithm. In an F2 population founded by a congenic high growth (HG) line and non-HG line, a highly additive effect due to the hg gene was detected on growth trajectories. Three QTL located on chromosomes 2 and X were identified to trigger significant additive and/or dominant effects on the process of growth. The most significant finding made from our model is that these QTL interact with the hg locus to affect the shapes of the growth process. Our model provides a powerful means for understanding the genetic architecture and regulation of growth rate and body size in mammals.

Original languageEnglish (US)
Pages (from-to)239-249
Number of pages11
JournalGenetics
Volume171
Issue number1
DOIs
StatePublished - Sep 1 2005

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Quantitative Trait Loci
Mutation
Growth
Body Size
Chromosomes, Human, Pair 2
Genes
Mammals

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Wu, Rongling ; Ma, Chang Xing ; Hou, Wei ; Corva, Pablo ; Medrano, Juan F. / Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice. In: Genetics. 2005 ; Vol. 171, No. 1. pp. 239-249.
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Functional mapping of quantitative trait loci that interact with the hg mutation to regulate growth trajectories in mice. / Wu, Rongling; Ma, Chang Xing; Hou, Wei; Corva, Pablo; Medrano, Juan F.

In: Genetics, Vol. 171, No. 1, 01.09.2005, p. 239-249.

Research output: Contribution to journalArticle

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