Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors

T Thomas Zacharia, Paul J. Eslinger

Research output: Contribution to journalArticle

Abstract

Function of cerebellum in control and coordination of motor function has been well established for several years. Recent functional magnetic resonance imaging (MRI) studies reveal activation of cerebellum with memory, speech and language tasks. We hypothesize that during every function in the brain signals are relayed to cerebellum. We seek to analyze cognitive, emotional and social functions of cerebellum in patients with brain tumors and epilepsy utilizing functional Magnetic Resonance Imaging. Fifty-one consecutive adult patients who underwent functional MRI examination were retrospectively analyzed for various activation patterns involving cerebellum. The neuropsychological battery of tasks assessed motor, language, memory, visual and auditory functions. Cognitive ability of all participants was assessed by Montreal cognitive assessment (MOCA). Patterns were analyzed for specific lobes and locations in the cerebellum. We found that simultaneous cerebellar activation is a consistent finding with brain activation during every functional MRI task that we tested except visual task. The patterns of functional MRI cerebellar activation were similar in both patient subgroups and control subjects compared to previously described patterns in normal subjects. Clin. Anat. 32:1053–1060, 2019.

Original languageEnglish (US)
Pages (from-to)1053-1060
Number of pages8
JournalClinical Anatomy
Volume32
Issue number8
DOIs
StatePublished - Nov 1 2019

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Brain Neoplasms
Cerebellum
Epilepsy
Magnetic Resonance Imaging
Language
Aptitude
Brain

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Histology

Cite this

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Functional MRI activation patterns of cerebellum in patients with epilepsy and brain tumors. / Zacharia, T Thomas; Eslinger, Paul J.

In: Clinical Anatomy, Vol. 32, No. 8, 01.11.2019, p. 1053-1060.

Research output: Contribution to journalArticle

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