Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames

Anton Nekrutenko, Jianbin He

Research output: Contribution to journalShort surveypeer-review

25 Scopus citations

Abstract

Eukaryotic genes with overlapping reading frames exemplify some of the most striking biological phenomena. Transcript of one such gene, the gene encoding X-box protein (XBP1), has evolved a mechanism for 'on-demand' switching of translation between two overlapping reading frames. Despite the existence of this elaborate system, only one reading frame was believed to be functional. Here, we show that XBP1 evolves in a fashion that is only consistent with functionality of both reading frames. Our study provides a novel evolutionary framework for the analysis of loci with overlapping reading frames, which can be used for identification and analyses of novel dual-coding genes.

Original languageEnglish (US)
Pages (from-to)645-648
Number of pages4
JournalTrends in Genetics
Volume22
Issue number12
DOIs
StatePublished - Dec 2006

All Science Journal Classification (ASJC) codes

  • Genetics

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