Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames

Anton Nekrutenko, Jianbin He

Research output: Contribution to journalShort survey

22 Citations (Scopus)

Abstract

Eukaryotic genes with overlapping reading frames exemplify some of the most striking biological phenomena. Transcript of one such gene, the gene encoding X-box protein (XBP1), has evolved a mechanism for 'on-demand' switching of translation between two overlapping reading frames. Despite the existence of this elaborate system, only one reading frame was believed to be functional. Here, we show that XBP1 evolves in a fashion that is only consistent with functionality of both reading frames. Our study provides a novel evolutionary framework for the analysis of loci with overlapping reading frames, which can be used for identification and analyses of novel dual-coding genes.

Original languageEnglish (US)
Pages (from-to)645-648
Number of pages4
JournalTrends in Genetics
Volume22
Issue number12
DOIs
StatePublished - Dec 1 2006

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Reading Frames
Overlapping Genes
Genes
Biological Phenomena
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

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Functionality of unspliced XBP1 is required to explain evolution of overlapping reading frames. / Nekrutenko, Anton; He, Jianbin.

In: Trends in Genetics, Vol. 22, No. 12, 01.12.2006, p. 645-648.

Research output: Contribution to journalShort survey

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