Functionalization of carboxylic anhydrides at α-carbon with hypervalent iodine reagents: One-pot conversion of anhydrides to 2-sulfonyloxycarboxylate esters

Jeffrey M. Goff, Michael Walter Justik, Gerald F. Koser

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The treatment of carboxylic anhydrides with iodine(III) sulfonate reagents at ca. 100°C and esterification of the reaction mixtures with MeOH/TsOH·H2O affords 2-sulfonyloxycarboxylate esters. This is consistent with enolic behavior in the anhydrides.

Original languageEnglish (US)
Pages (from-to)5597-5599
Number of pages3
JournalTetrahedron Letters
Volume42
Issue number33
DOIs
StatePublished - Aug 13 2001

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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