Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Dale L. Boger, Nancy Ellen Haynes, Mark S. Warren, Lata T. Gooljarsingh, Joseph Ramcharan, Paul A. Kitos, Stephen J. Benkovic

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

Original languageEnglish (US)
Pages (from-to)1831-1838
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume5
Issue number9
DOIs
StatePublished - Sep 1997

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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