Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase

Dale L. Boger, Nancy Ellen Haynes, Mark S. Warren, Lata T. Gooljarsingh, Joseph Ramcharan, Paul A. Kitos, Stephen Benkovic

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Abstract

A series of TDAF-based analogues of 10-formyl-tetrahydrofolic acid are examined in efforts to explore the formyl transfer region of GAR Tfase and AICAR Tfase.

Original languageEnglish (US)
Pages (from-to)1831-1838
Number of pages8
JournalBioorganic and Medicinal Chemistry
Volume5
Issue number9
DOIs
Publication statusPublished - Sep 1 1997

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Boger, D. L., Haynes, N. E., Warren, M. S., Gooljarsingh, L. T., Ramcharan, J., Kitos, P. A., & Benkovic, S. (1997). Functionalized analogues of 5,8,10-trideazafolate as potential inhibitors of GAR Tfase or AICAR Tfase. Bioorganic and Medicinal Chemistry, 5(9), 1831-1838. https://doi.org/10.1016/S0968-0896(97)00121-1