Functionally gradient tissue scaffold design and deposition path planning for bio-additive processes

A. K M Khoda, Ibrahim Tarik Ozbolat, Bahattin Koc

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A layer-based tissue scaffold is designed with heterogeneous internal architecture. The proposed layer-based design uses a bi-layer pattern of radial and spiral layer consecutively to generate functionally gradient porosity following the geometry of the scaffold. Medial region is constructed from medial axis and used as an internal geometric feature for each layer. The radial layers are generated with sub-region channels by connecting the boundaries of the medial region and the layer's outer contour. Proper connections with allowable geometric properties are ensured by applying optimization algorithms. Iso-porosity regions are determined by dividing the sub-regions into pore cells. The combination of consecutive layers generates the pore cells with desired pore sizes. To ensure the fabrication of the designed scaffolds, both contours have been optimized for a continuous, interconnected, and smooth deposition path-planning. The proposed methodologies can generate the structure with gradient (linear or non-linear), variational or constant porosity that can provide localized control of variational porosity along the scaffold architecture. The designed porous structures can be fabricated using bio-additive fabrication processes.

Original languageEnglish (US)
Title of host publicationIIE Annual Conference and Expo 2013
PublisherInstitute of Industrial Engineers
Pages2253-2262
Number of pages10
StatePublished - 2013
EventIIE Annual Conference and Expo 2013 - San Juan, Puerto Rico
Duration: May 18 2013May 22 2013

Other

OtherIIE Annual Conference and Expo 2013
CountryPuerto Rico
CitySan Juan
Period5/18/135/22/13

All Science Journal Classification (ASJC) codes

  • Industrial and Manufacturing Engineering

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  • Cite this

    Khoda, A. K. M., Ozbolat, I. T., & Koc, B. (2013). Functionally gradient tissue scaffold design and deposition path planning for bio-additive processes. In IIE Annual Conference and Expo 2013 (pp. 2253-2262). Institute of Industrial Engineers.