Functions of polyamines in mammals

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth and development.

Original languageEnglish (US)
Pages (from-to)14904-14912
Number of pages9
JournalJournal of Biological Chemistry
Volume291
Issue number29
DOIs
StatePublished - Jul 15 2016

Fingerprint

Mammals
Spermidine
Polyamines
Spermine
Spermine Synthase
Cell proliferation
Protein Biosynthesis
Ion Channels
Growth and Development
Nucleic Acids
Cell Differentiation
Proteins
Cells
Cell Proliferation
Apoptosis
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

@article{5949439f2a5643e98a8b709784cb9d83,
title = "Functions of polyamines in mammals",
abstract = "The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth and development.",
author = "Pegg, {Anthony E.}",
year = "2016",
month = "7",
day = "15",
doi = "10.1074/jbc.R116.731661",
language = "English (US)",
volume = "291",
pages = "14904--14912",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.",
number = "29",

}

Functions of polyamines in mammals. / Pegg, Anthony E.

In: Journal of Biological Chemistry, Vol. 291, No. 29, 15.07.2016, p. 14904-14912.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Functions of polyamines in mammals

AU - Pegg, Anthony E.

PY - 2016/7/15

Y1 - 2016/7/15

N2 - The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth and development.

AB - The content of spermidine and spermine in mammalian cells has important roles in protein and nucleic acid synthesis and structure, protection from oxidative damage, activity of ion channels, cell proliferation, differentiation, and apoptosis. Spermidine is essential for viability and acts as the precursor of hypusine, a post-translational addition to eIF5A allowing the translation of mRNAs encoding proteins containing polyproline tracts. Studies with Gy mice and human patients with the very rare X-linked genetic condition Snyder-Robinson syndrome that both lack spermine synthase show clearly that the correct spermine:spermidine ratio is critical for normal growth and development.

UR - http://www.scopus.com/inward/record.url?scp=84978822644&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978822644&partnerID=8YFLogxK

U2 - 10.1074/jbc.R116.731661

DO - 10.1074/jbc.R116.731661

M3 - Review article

C2 - 27268251

AN - SCOPUS:84978822644

VL - 291

SP - 14904

EP - 14912

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

SN - 0021-9258

IS - 29

ER -