Fungal pathogen reduces potential for malaria transmission

Simon Blanford, Brian H.K. Chan, Nina Jenkins, Derek Sim, Ruth J. Turner, Andrew F. Read, Matt B. Thomas

Research output: Contribution to journalArticlepeer-review

237 Scopus citations

Abstract

Using a rodent malaria model, we found that exposure to surfaces treated with fungal entomopathogens following an infectious blood meal reduced the number of mosquitoes able to transmit malaria by a factor of about 80. Fungal infection, achieved through contact with both solid surfaces and netting for durations well within the typical post-feed resting periods, was sufficient to cause >90% mortality. Daily mortality rates escalated dramatically around the time of sporozoite maturation, and infected mosquitoes showed reduced propensity to blood feed. Residual sprays of fungal biopesticides might replace or supplement chemical insecticides for malaria control, particularly in areas of high insecticide resistance.

Original languageEnglish (US)
Pages (from-to)1638-1641
Number of pages4
JournalScience
Volume308
Issue number5728
DOIs
StatePublished - Jun 10 2005

All Science Journal Classification (ASJC) codes

  • General

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