In the interest of developing a more effective fungicide to combat Dutch elm disease, our laboratories have synthesized several triphenyltin carboxylates and some 1:1 addition compounds of triphenyltin chloride using 2,3-disubstituted thiazolidin-4-ones as the ligand and screened them in vitro against Ceratocystis ulmi, the causative agent of Dutch elm disease, using a shake culture method. Elemental analyses and spectroscopic data indicate that the structures of the carboxylates in the solid state are monomeric with a tetrahedral tin atom with the exception of the furan-2-carboxylic acid derivative, which was found to be polymeric. The triphenyltin chloride adducts are trigonal-bipyramidal with the three phenyl groups in the equatorial plane. Far-infrared data indicate that the three phenyl groups are not co-planar. Screening results for both series of organotins indicate that these two classes of compounds are effective inhibitors of Ceratocystis ulmi, with the adducts having a higher activity. The furan-2-carboxylic acid derivative has a markedly decreased activity compared with the other carboxylates and this is attributed to its polymeric structure.
|Original language||English (US)|
|Number of pages||6|
|Journal||Applied Organometallic Chemistry|
|State||Published - Jan 1998|
All Science Journal Classification (ASJC) codes
- Inorganic Chemistry