Funmap2: An R package for QTL mapping using longitudinal phenotypes

Nating Wang, Tinyi Chu, Jiangtao Luo, Rongling Wu, Zhong Wang

Research output: Contribution to journalArticle

Abstract

Quantitative trait locus (QTL) mapping has been used as a powerful tool for inferring the complexity of the genetic architecture that underlies phenotypic traits. This approach has shown its unique power to map the developmental genetic architecture of complex traits by implementing longitudinal data analysis. Here, we introduce the R package Funmap2 based on the functional mapping framework, which integrates prior biological knowledge into the statistical model. Specifically, the functional mapping framework is engineered to include longitudinal curves that describe the genetic effects and the covariance matrix of the trait of interest. Funmap2 chooses the type of longitudinal curve and covariance matrix automatically using information criteria. Funmap2 is available for download at https://github.com/wzhy2000/Funmap2.

Original languageEnglish (US)
Article numbere7008
JournalPeerJ
Volume2019
Issue number5
DOIs
StatePublished - Jan 1 2019

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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