Furoxan-Bearing Micelles for Nitric Oxide Delivery

Urara Hasegawa, Tengjiao Wang, Jerry J.Y. Chen, Hiroshi Uyama, André J. van der Vlies

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Furoxans, or 1,2,5-oxadiazole-N-oxides, are a class of nitric oxide (NO)-donating compounds that release NO in response to thiol-containing molecules. In this study, polymeric micelles bearing furoxan moieties are prepared from an amphiphilic block copolymer consisting of a hydrophobic furoxan-bearing block and a hydrophilic poly(N-acryloylmorpholine) block. The block copolymer is prepared using a combination of the reversible addition–fragmentation chain transfer polymerization and the copper-catalyzed Huisgen cycloaddition techniques. The block copolymers form spherical micelles with a diameter of 50 nm by self-assembly in water. The micelles release NO in response to cysteine and show improved stability against hydrolytic decomposition. Furthermore, the micelles show a synergistic anti-proliferative effect with ibuprofen in human colon cancer cells. (Figure presented.) .

Original languageEnglish (US)
Pages (from-to)1009-1018
Number of pages10
JournalMacromolecular Bioscience
DOIs
StatePublished - Jul 1 2016

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry

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