Further tolyporphins from the Blue-Green alga Tolypothrix nodosa.

Michèle R. Prinsep, Gregory M.L. Patterson, Linda K. Larsen, Charles D. Smith

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Abstract

Eight new porphinoids, tolyporphins B-I (2-9), along with the known tolyporphin A (1) have been isolated from a lipophilic extract of the Pacific cyanophyte, Tolypothrix nodosa. Their structures have been elucidated using 1- and 2-D NMR spectroscopic experiments and the tolyporphins showed varying activities in drug accumulation and competitive binding assays for multidrug resistance (MDR) reversal.

Original languageEnglish (US)
Pages (from-to)10523-10530
Number of pages8
JournalTetrahedron
Volume51
Issue number38
DOIs
StatePublished - Sep 18 1995

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., & Smith, C. D. (1995). Further tolyporphins from the Blue-Green alga Tolypothrix nodosa. Tetrahedron, 51(38), 10523-10530. https://doi.org/10.1016/0040-4020(95)00615-F