Further validation of a quadruplex STR DNA typing system: a collaborative effort to identify victims of a mass disaster

T. M. Clayton, J. P. Whitaker, D. L. Fisher, D. A. Lee, M. M. Holland, V. W. Weedn, C. N. Maguire, J. A. DiZinno, C. P. Kimpton, P. Gill

Research output: Contribution to journalArticle

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Abstract

The relatively new, PCR-based technique of Short Tandem Repeat (STR) profiling has been used in the identification of the victims of a mass disaster. The analysis relied upon a recently developed multiplex reaction and the use of automated fluorescence technology to simultaneously analyse four tetrameric STR loci. The performance of the 'quadruplex' test was assessed by use of a collaborative study incorporating a blind trial and was demonstrated to be accurate, reliable and robust. Furthermore, the system proved to be highly successful despite the fact that many of the samples from the mass disaster scene were extremely degraded. The high success rate coupled with the discrimination power of the system enabled many severely decomposed human remains to be positively identified.

Original languageEnglish (US)
Pages (from-to)17-25
Number of pages9
JournalForensic science international
Volume76
Issue number1
DOIs
StatePublished - Nov 30 1995

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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    Clayton, T. M., Whitaker, J. P., Fisher, D. L., Lee, D. A., Holland, M. M., Weedn, V. W., Maguire, C. N., DiZinno, J. A., Kimpton, C. P., & Gill, P. (1995). Further validation of a quadruplex STR DNA typing system: a collaborative effort to identify victims of a mass disaster. Forensic science international, 76(1), 17-25. https://doi.org/10.1016/0379-0738(95)01788-7