Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): Synthesis and initial structure-activity relationships

James Kempson, William J. Pitts, Joseph Barbosa, Junqing Guo, Omonike Omotoso, Andrew Watson, Karen Stebbins, Gary C. Starling, John H. Dodd, Joel C. Barrish, Raymond Felix, Karl Fischer

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.

Original languageEnglish (US)
Pages (from-to)1829-1833
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume15
Issue number7
DOIs
StatePublished - Apr 1 2005

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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