Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

Derek A. Persons, Robert Paulson, Melanie R. Loyd, Mark T. Herley, Sara M. Bodner, Alan Bernstein, Pamela H. Correll, Paul A. Ney

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Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalNature Genetics
Volume23
Issue number2
DOIs
StatePublished - Oct 1 1999

All Science Journal Classification (ASJC) codes

  • Genetics

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    Persons, D. A., Paulson, R., Loyd, M. R., Herley, M. T., Bodner, S. M., Bernstein, A., Correll, P. H., & Ney, P. A. (1999). Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nature Genetics, 23(2), 159-165. https://doi.org/10.1038/13787