Fv2 encodes a truncated form of the Stk receptor tyrosine kinase

Derek A. Persons, Robert Paulson, Melanie R. Loyd, Mark T. Herley, Sara M. Bodner, Alan Bernstein, Pamela H. Correll, Paul A. Ney

Research output: Contribution to journalArticle

124 Citations (Scopus)

Abstract

The Friend virus susceptibility 2 (Fv2) locus encodes a dominant host factor that confers susceptibility to Friend virus-induced erythroleukaemia in mice. We mapped Fv2 to a 1.0-Mb interval that also contained the gene (Ron) encoding the stem cell kinase receptor (Stk). A truncated form of Stk (Sf-stk), which was the most abundant form of Stk in Fv2-sensitive (Fv2(ss)) erythroid cells, was not expressed in Fv2 resistant (Fv2(rr)) cells. Enforced expression of Sf-stk conferred susceptibility to Friend disease, whereas targeted disruption of Ron caused resistance. We conclude that the Fv2 locus encodes Ron, and that a naturally expressed, truncated form of Stk confers susceptibility to Friend virus-induced erythroleukaemia.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalNature Genetics
Volume23
Issue number2
DOIs
StatePublished - Oct 1 1999

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Friend murine leukemia virus
Receptor Protein-Tyrosine Kinases
Leukemia, Erythroblastic, Acute
Erythroid Cells
Phosphotransferases
Stem Cells

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Persons, D. A., Paulson, R., Loyd, M. R., Herley, M. T., Bodner, S. M., Bernstein, A., ... Ney, P. A. (1999). Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nature Genetics, 23(2), 159-165. https://doi.org/10.1038/13787
Persons, Derek A. ; Paulson, Robert ; Loyd, Melanie R. ; Herley, Mark T. ; Bodner, Sara M. ; Bernstein, Alan ; Correll, Pamela H. ; Ney, Paul A. / Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. In: Nature Genetics. 1999 ; Vol. 23, No. 2. pp. 159-165.
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Persons, DA, Paulson, R, Loyd, MR, Herley, MT, Bodner, SM, Bernstein, A, Correll, PH & Ney, PA 1999, 'Fv2 encodes a truncated form of the Stk receptor tyrosine kinase', Nature Genetics, vol. 23, no. 2, pp. 159-165. https://doi.org/10.1038/13787

Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. / Persons, Derek A.; Paulson, Robert; Loyd, Melanie R.; Herley, Mark T.; Bodner, Sara M.; Bernstein, Alan; Correll, Pamela H.; Ney, Paul A.

In: Nature Genetics, Vol. 23, No. 2, 01.10.1999, p. 159-165.

Research output: Contribution to journalArticle

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AU - Persons, Derek A.

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AU - Loyd, Melanie R.

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AU - Bernstein, Alan

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AU - Ney, Paul A.

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Persons DA, Paulson R, Loyd MR, Herley MT, Bodner SM, Bernstein A et al. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nature Genetics. 1999 Oct 1;23(2):159-165. https://doi.org/10.1038/13787