GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The neurotransmitter Γ-aminobutyric acid (GABA) confers neural inhibition in the central nervous system primarily by acting at GABA-gated chloride channels named GABAA and GABAc receptors. Structurally and functionally distinct receptor subtypes are assembled from multiple homologous subunits. Receptor heterogeneity is, however, limited by only partial overlap in the expression pattern of the different subunits and by the rules that govern receptor assembly. GABAc receptors are homo- or heteromers composed of Ρl-3 subunits. Formation of GABAA receptors involves initial assembly of α and ß subunits followed by the addition of a third type of subunit, most commonly the Γ2 subunit.

Original languageEnglish (US)
Title of host publicationReceptor and Ion-Channel Trafficking
Subtitle of host publicationCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
PublisherOxford University Press
ISBN (Electronic)9780191724763
ISBN (Print)9780192632241
DOIs
StatePublished - Mar 22 2012

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Medicine(all)

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