GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The neurotransmitter Γ-aminobutyric acid (GABA) confers neural inhibition in the central nervous system primarily by acting at GABA-gated chloride channels named GABAA and GABAc receptors. Structurally and functionally distinct receptor subtypes are assembled from multiple homologous subunits. Receptor heterogeneity is, however, limited by only partial overlap in the expression pattern of the different subunits and by the rules that govern receptor assembly. GABAc receptors are homo- or heteromers composed of Ρl-3 subunits. Formation of GABAA receptors involves initial assembly of α and ß subunits followed by the addition of a third type of subunit, most commonly the Γ2 subunit.

Original languageEnglish (US)
Title of host publicationReceptor and Ion-Channel Trafficking
Subtitle of host publicationCell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels
PublisherOxford University Press
ISBN (Electronic)9780191724763
ISBN (Print)9780192632241
DOIs
StatePublished - Mar 22 2012

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GABA-A Receptors
gamma-Aminobutyric Acid
Cluster Analysis
Neural Inhibition
Aminobutyrates
Chloride Channels
Neurotransmitter Agents
Central Nervous System
GABA-C receptor

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Medicine(all)

Cite this

Luscher, B. (2012). GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover. In Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192632241.003.0009
Luscher, Bernhard. / GABAA and GABAC receptors : Regulation of assembly, localization, clustering and turnover. Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels. Oxford University Press, 2012.
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Luscher, B 2012, GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover. in Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels. Oxford University Press. https://doi.org/10.1093/acprof:oso/9780192632241.003.0009

GABAA and GABAC receptors : Regulation of assembly, localization, clustering and turnover. / Luscher, Bernhard.

Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels. Oxford University Press, 2012.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Luscher B. GABAA and GABAC receptors: Regulation of assembly, localization, clustering and turnover. In Receptor and Ion-Channel Trafficking: Cell Biology of Ligand-Gated and Voltage-Sensitive Ion Channels. Oxford University Press. 2012 https://doi.org/10.1093/acprof:oso/9780192632241.003.0009