GABAergic neurotransmission within the reticular part of the substantia nigra (SNR): role for switching motor patterns and performance of movements

Christine Marcelle Heim, M. Schwarz, T. Klockgether, R. Jaspers, A. R. Cools, K. H. Sontag

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In order to investigate the role of GABAergic neurotransmission within the reticular part of substantia nigra (SNR) in the switching of motor patterns and the performance of movements, cats trained to walk on the running belt of a treadmill at constant speed were subjected to three different tests: (1) a food dispenser test measuring the animals' capacity to switch motor patterns in order to get access to food during walking; (2) an obstacle test measuring the animals' capacity to switch motor patterns in reaction to incoming obstacles; (3) EMG recording of two representative antagonistic muscles of the hindlimb during walking on the treadmill. Local injection of a moderate dose of the GABA antagonist picrotoxin (PTX; 250-500 ng/0.5 μl) into the SNR disrupted the animals' capacity to switch motor patterns in the food dispenser test, but not in the obstacle test. These animals displayed normal EMG patterns during walking. Higher doses of intranigral injections of PTX, however, impaired the execution of movements per se as detected by an increased number of 'faults' in the obstacle test and pathological EMG patterns during walking. These experiments support the view that (1) the SNR plays a distinct role for switching motor patterns; (2) the SNR is involved in the control of movements per se; (3) the degree of motor disorder depends on the degree of pathology within this brain structure.

Original languageEnglish (US)
Pages (from-to)375-381
Number of pages7
JournalExperimental Brain Research
Volume63
Issue number2
DOIs
StatePublished - Jul 1 1986

Fingerprint

Substantia Nigra
Synaptic Transmission
Walking
Food
GABA Antagonists
Picrotoxin
Injections
Hindlimb
Running
Cats
Pathology
Muscles
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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abstract = "In order to investigate the role of GABAergic neurotransmission within the reticular part of substantia nigra (SNR) in the switching of motor patterns and the performance of movements, cats trained to walk on the running belt of a treadmill at constant speed were subjected to three different tests: (1) a food dispenser test measuring the animals' capacity to switch motor patterns in order to get access to food during walking; (2) an obstacle test measuring the animals' capacity to switch motor patterns in reaction to incoming obstacles; (3) EMG recording of two representative antagonistic muscles of the hindlimb during walking on the treadmill. Local injection of a moderate dose of the GABA antagonist picrotoxin (PTX; 250-500 ng/0.5 μl) into the SNR disrupted the animals' capacity to switch motor patterns in the food dispenser test, but not in the obstacle test. These animals displayed normal EMG patterns during walking. Higher doses of intranigral injections of PTX, however, impaired the execution of movements per se as detected by an increased number of 'faults' in the obstacle test and pathological EMG patterns during walking. These experiments support the view that (1) the SNR plays a distinct role for switching motor patterns; (2) the SNR is involved in the control of movements per se; (3) the degree of motor disorder depends on the degree of pathology within this brain structure.",
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GABAergic neurotransmission within the reticular part of the substantia nigra (SNR) : role for switching motor patterns and performance of movements. / Heim, Christine Marcelle; Schwarz, M.; Klockgether, T.; Jaspers, R.; Cools, A. R.; Sontag, K. H.

In: Experimental Brain Research, Vol. 63, No. 2, 01.07.1986, p. 375-381.

Research output: Contribution to journalArticle

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