Gamma-delta T-cell lymphoma arising in a long-standing cutaneous plaque

Liaqat Ali, Michelle R. Young, Michael G. Bayerl, Klaus F. Helm, Loren E. Clarke

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The precise classification and characterization of primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) has been hindered by clinical and morphologic features that overlap with other lymphomas, especially subcutaneous panniculitis-like T cell lymphoma (SPTCL). The recent World Health Organization/European Organization for Research and Treatment of Cancer (WHO/EORTC) classification distinguishes the more aggressive PCGD-TCL from the usually indolent SPTCL, however. We report a 30-year-old woman with an indurated violaceous plaque on the left cheek that had been present for several years. Biopsies showed a dense lymphocytic infiltrate involving the subcutis and dermis that consisted mostly of small and medium-sized lymphocytes, some with irregular nuclear contours and dense chromatin. These cells were positive for TIA-1, TCR-gamma and CD8, but negative for beta-F1 and granzyme-B. Staging with positron emission tomography-computed tomography (PET/CT), CBC and bone marrow with flow cytometry identified lymphadenopathy as well as blood and marrow involvement by an abnormal TCRgd-positive T-cell proliferation (Ann Arbor Stage IV). The patient's history of a long-standing lesion in this case is unusual, in that gamma-delta T-cell lymphomas are typically rapidly progressive neoplasms. As such, it raises the possibility of 'transformation' of a long-standing inflammatory process into an overt lymphoma.

Original languageEnglish (US)
Pages (from-to)987-991
Number of pages5
JournalJournal of Cutaneous Pathology
Volume42
Issue number12
DOIs
StatePublished - Dec 1 2015

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Somatostatin-Secreting Cells
T-Cell Lymphoma
Skin
Lymphoma
Bone Marrow
Granzymes
Cheek
Dermis
Chromatin
Neoplasms
Flow Cytometry
Cell Proliferation
Organizations
Lymphocytes
T-Lymphocytes
Biopsy
Research
Subcutaneous panniculitis-like T-cell lymphoma
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

Cite this

Ali, Liaqat ; Young, Michelle R. ; Bayerl, Michael G. ; Helm, Klaus F. ; Clarke, Loren E. / Gamma-delta T-cell lymphoma arising in a long-standing cutaneous plaque. In: Journal of Cutaneous Pathology. 2015 ; Vol. 42, No. 12. pp. 987-991.
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Gamma-delta T-cell lymphoma arising in a long-standing cutaneous plaque. / Ali, Liaqat; Young, Michelle R.; Bayerl, Michael G.; Helm, Klaus F.; Clarke, Loren E.

In: Journal of Cutaneous Pathology, Vol. 42, No. 12, 01.12.2015, p. 987-991.

Research output: Contribution to journalArticle

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