Ganciclovir phrophylaxis delays but does not prevent cytomegalovirus infection in renal transplant recipients

A. Israni, K. Krok, D. Cohen, E. Blumberg, Roy D. Bloom

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cytomegalovirus (CMV) infection is associated with reduced graft and patient survival among renal transplant recipients. The purpose of this study was to examine the effect of routine prophylaxis with 12 weeks of oral ganciclovir on the incidence of CMV infection in a center that predominantly uses antibody induction together with tacrolimus/mycophenolate mofetil-based maintenance immunosuppressive therapy. The control group consisted of a historical patient cohort transplanted immediately prior to the use of oral ganciclovir prophylaxis. The use of tacrolimus (88% vs 77%, P = .02) and cytolytic therapy (81% vs 46%, P < .0001) was likewise greater among patients who received ganciclovir prophylaxis. CMV infection occurred in 20 (9%) patients in the ganciclovir era and 4 (3%) patients in the preganciclovir era (P = .003). The mean time to CMV infection was longer in patients who received ganciclovir prophylaxis than in patients in the preganciclovir era (23.4 ± 10.9 weeks vs 9.8 ± 5.6 weeks, P = .03). We conclude that 12 weeks of ganciclovir prophylaxis delays but does not prevent CMV infection from occurring in renal transplant recipients. These results suggest that with the use of 12 weeks of ganciclovir prophylaxis, vigilance for CMV infection is needed well beyond 24 weeks posttransplant.

Original languageEnglish (US)
Pages (from-to)3019-3024
Number of pages6
JournalTransplantation proceedings
Volume36
Issue number10
DOIs
StatePublished - Jan 1 2004

Fingerprint

Ganciclovir
Cytomegalovirus Infections
Kidney
Tacrolimus
Mycophenolic Acid
Graft Survival
Immunosuppressive Agents
Transplant Recipients
Maintenance
Control Groups
Antibodies
Incidence
Therapeutics

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Israni, A. ; Krok, K. ; Cohen, D. ; Blumberg, E. ; Bloom, Roy D. / Ganciclovir phrophylaxis delays but does not prevent cytomegalovirus infection in renal transplant recipients. In: Transplantation proceedings. 2004 ; Vol. 36, No. 10. pp. 3019-3024.
@article{2132be7441e7423bbae25adc5f030452,
title = "Ganciclovir phrophylaxis delays but does not prevent cytomegalovirus infection in renal transplant recipients",
abstract = "Cytomegalovirus (CMV) infection is associated with reduced graft and patient survival among renal transplant recipients. The purpose of this study was to examine the effect of routine prophylaxis with 12 weeks of oral ganciclovir on the incidence of CMV infection in a center that predominantly uses antibody induction together with tacrolimus/mycophenolate mofetil-based maintenance immunosuppressive therapy. The control group consisted of a historical patient cohort transplanted immediately prior to the use of oral ganciclovir prophylaxis. The use of tacrolimus (88{\%} vs 77{\%}, P = .02) and cytolytic therapy (81{\%} vs 46{\%}, P < .0001) was likewise greater among patients who received ganciclovir prophylaxis. CMV infection occurred in 20 (9{\%}) patients in the ganciclovir era and 4 (3{\%}) patients in the preganciclovir era (P = .003). The mean time to CMV infection was longer in patients who received ganciclovir prophylaxis than in patients in the preganciclovir era (23.4 ± 10.9 weeks vs 9.8 ± 5.6 weeks, P = .03). We conclude that 12 weeks of ganciclovir prophylaxis delays but does not prevent CMV infection from occurring in renal transplant recipients. These results suggest that with the use of 12 weeks of ganciclovir prophylaxis, vigilance for CMV infection is needed well beyond 24 weeks posttransplant.",
author = "A. Israni and K. Krok and D. Cohen and E. Blumberg and Bloom, {Roy D.}",
year = "2004",
month = "1",
day = "1",
doi = "10.1016/j.transproceed.2004.10.091",
language = "English (US)",
volume = "36",
pages = "3019--3024",
journal = "Transplantation Proceedings",
issn = "0041-1345",
publisher = "Elsevier USA",
number = "10",

}

Ganciclovir phrophylaxis delays but does not prevent cytomegalovirus infection in renal transplant recipients. / Israni, A.; Krok, K.; Cohen, D.; Blumberg, E.; Bloom, Roy D.

In: Transplantation proceedings, Vol. 36, No. 10, 01.01.2004, p. 3019-3024.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ganciclovir phrophylaxis delays but does not prevent cytomegalovirus infection in renal transplant recipients

AU - Israni, A.

AU - Krok, K.

AU - Cohen, D.

AU - Blumberg, E.

AU - Bloom, Roy D.

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Cytomegalovirus (CMV) infection is associated with reduced graft and patient survival among renal transplant recipients. The purpose of this study was to examine the effect of routine prophylaxis with 12 weeks of oral ganciclovir on the incidence of CMV infection in a center that predominantly uses antibody induction together with tacrolimus/mycophenolate mofetil-based maintenance immunosuppressive therapy. The control group consisted of a historical patient cohort transplanted immediately prior to the use of oral ganciclovir prophylaxis. The use of tacrolimus (88% vs 77%, P = .02) and cytolytic therapy (81% vs 46%, P < .0001) was likewise greater among patients who received ganciclovir prophylaxis. CMV infection occurred in 20 (9%) patients in the ganciclovir era and 4 (3%) patients in the preganciclovir era (P = .003). The mean time to CMV infection was longer in patients who received ganciclovir prophylaxis than in patients in the preganciclovir era (23.4 ± 10.9 weeks vs 9.8 ± 5.6 weeks, P = .03). We conclude that 12 weeks of ganciclovir prophylaxis delays but does not prevent CMV infection from occurring in renal transplant recipients. These results suggest that with the use of 12 weeks of ganciclovir prophylaxis, vigilance for CMV infection is needed well beyond 24 weeks posttransplant.

AB - Cytomegalovirus (CMV) infection is associated with reduced graft and patient survival among renal transplant recipients. The purpose of this study was to examine the effect of routine prophylaxis with 12 weeks of oral ganciclovir on the incidence of CMV infection in a center that predominantly uses antibody induction together with tacrolimus/mycophenolate mofetil-based maintenance immunosuppressive therapy. The control group consisted of a historical patient cohort transplanted immediately prior to the use of oral ganciclovir prophylaxis. The use of tacrolimus (88% vs 77%, P = .02) and cytolytic therapy (81% vs 46%, P < .0001) was likewise greater among patients who received ganciclovir prophylaxis. CMV infection occurred in 20 (9%) patients in the ganciclovir era and 4 (3%) patients in the preganciclovir era (P = .003). The mean time to CMV infection was longer in patients who received ganciclovir prophylaxis than in patients in the preganciclovir era (23.4 ± 10.9 weeks vs 9.8 ± 5.6 weeks, P = .03). We conclude that 12 weeks of ganciclovir prophylaxis delays but does not prevent CMV infection from occurring in renal transplant recipients. These results suggest that with the use of 12 weeks of ganciclovir prophylaxis, vigilance for CMV infection is needed well beyond 24 weeks posttransplant.

UR - http://www.scopus.com/inward/record.url?scp=21244500603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21244500603&partnerID=8YFLogxK

U2 - 10.1016/j.transproceed.2004.10.091

DO - 10.1016/j.transproceed.2004.10.091

M3 - Article

C2 - 15686685

AN - SCOPUS:21244500603

VL - 36

SP - 3019

EP - 3024

JO - Transplantation Proceedings

JF - Transplantation Proceedings

SN - 0041-1345

IS - 10

ER -