Gangliosides

Glycosphingolipids essential for normal neural development and function

Cara-Lynne Schengrund

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.

Original languageEnglish (US)
Pages (from-to)397-406
Number of pages10
JournalTrends in Biochemical Sciences
Volume40
Issue number7
DOIs
StatePublished - Jan 1 2015

Fingerprint

Glycosphingolipids
Gangliosides
Brain
Cell signaling
Lipids
Signal transduction
Dementia
Signal Transduction
Aging of materials
Phenotype
Chemical analysis

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology

Cite this

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title = "Gangliosides: Glycosphingolipids essential for normal neural development and function",
abstract = "Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.",
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Gangliosides : Glycosphingolipids essential for normal neural development and function. / Schengrund, Cara-Lynne.

In: Trends in Biochemical Sciences, Vol. 40, No. 7, 01.01.2015, p. 397-406.

Research output: Contribution to journalReview article

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T1 - Gangliosides

T2 - Glycosphingolipids essential for normal neural development and function

AU - Schengrund, Cara-Lynne

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AB - Lipid rafts, sites of signal transduction, are enriched in glycosphingolipids (GSLs). Gangliosides, a class of GSLs found in greatest concentration in the grey matter of the brain, can affect neuronal function by modulating cell signaling. This review summarizes changes in ganglioside expression during brain development, the specific effects they induce, and makes observations about their possible role(s) in dementing diseases. Given that the average lifespan of individuals in many countries has increased, and that aging is accompanied by an increasing probability of dementia, understanding how changes in the GSL composition of lipid rafts may contribute to the cell biological basis of a specific dementing phenotype is an important area of study.

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