Gas chromatographic/mass spectrometric analysis of human serum for non-ortho (coplanar) and ortho substituted polychlorinated biphenyls using isotope-dilution mass spectrometry

D. G. Patterson, C. R. Lapeza, E. R. Barnhart, D. F. Groce, V. W. Burse

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

We have synthesized in our laboratory all of the totally carbon-13-labeled PCBs normally found in human tissues. The mixture of carbon-13-labeled PCBs consists of more than 50 congeners including the 13c12-labeled, coplanar, non-ortho substituted PCBs. We used this spiking material to prepare analytical standards at various concentration levels, and established standard curves using isotope-dilution mass spectrometry for each congener over a range of concentrations normally found in human samples. The PCBs were analyzed on a Finnigan MAT 4500 in either the electron-impact or negative-ion chemical ionization mode on a DB-5 capillary column.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalChemosphere
Volume19
Issue number1-6
DOIs
StatePublished - 1989

Fingerprint

Polychlorinated Biphenyls
Polychlorinated biphenyls
Isotopes
Dilution
Mass spectrometry
serum
PCB
Mass Spectrometry
dilution
mass spectrometry
Gases
isotope
Serum
gas
carbon isotope
Carbon
Ionization
ionization
Negative ions
Electrons

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

Cite this

Patterson, D. G. ; Lapeza, C. R. ; Barnhart, E. R. ; Groce, D. F. ; Burse, V. W. / Gas chromatographic/mass spectrometric analysis of human serum for non-ortho (coplanar) and ortho substituted polychlorinated biphenyls using isotope-dilution mass spectrometry. In: Chemosphere. 1989 ; Vol. 19, No. 1-6. pp. 127-134.
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Gas chromatographic/mass spectrometric analysis of human serum for non-ortho (coplanar) and ortho substituted polychlorinated biphenyls using isotope-dilution mass spectrometry. / Patterson, D. G.; Lapeza, C. R.; Barnhart, E. R.; Groce, D. F.; Burse, V. W.

In: Chemosphere, Vol. 19, No. 1-6, 1989, p. 127-134.

Research output: Contribution to journalArticle

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AU - Patterson, D. G.

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AU - Burse, V. W.

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