Gas chromatographic/mass spectrometric analysis of human serum for non-ortho (coplanar) and ortho substituted polychlorinated biphenyls using isotope-dilution mass spectrometry

D. G. Patterson, C. R. Lapeza, E. R. Barnhart, D. F. Groce, V. W. Burse

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

We have synthesized in our laboratory all of the totally carbon-13-labeled PCBs normally found in human tissues. The mixture of carbon-13-labeled PCBs consists of more than 50 congeners including the 13c12-labeled, coplanar, non-ortho substituted PCBs. We used this spiking material to prepare analytical standards at various concentration levels, and established standard curves using isotope-dilution mass spectrometry for each congener over a range of concentrations normally found in human samples. The PCBs were analyzed on a Finnigan MAT 4500 in either the electron-impact or negative-ion chemical ionization mode on a DB-5 capillary column.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalChemosphere
Volume19
Issue number1-6
DOIs
StatePublished - 1989

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Chemistry(all)
  • Pollution
  • Health, Toxicology and Mutagenesis

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