We have synthesized in our laboratory all of the totally carbon-13-labeled PCBs normally found in human tissues. The mixture of carbon-13-labeled PCBs consists of more than 50 congeners including the 13c12-labeled, coplanar, non-ortho substituted PCBs. We used this spiking material to prepare analytical standards at various concentration levels, and established standard curves using isotope-dilution mass spectrometry for each congener over a range of concentrations normally found in human samples. The PCBs were analyzed on a Finnigan MAT 4500 in either the electron-impact or negative-ion chemical ionization mode on a DB-5 capillary column.
All Science Journal Classification (ASJC) codes
- Environmental Engineering
- Environmental Chemistry
- Health, Toxicology and Mutagenesis