Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation

Robert E. Cilley, John R. Wesley, Joseph B. Zwischenberger, Robert H. Bartlett

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Closed-circuit spirometry techniques were used to study gas exchange (oxygen and carbon dioxide transport) across the native lung and membrane lung in ten neonates treated with extracorporeal membrane oxygenation (ECMO). Initially there was negligible oxygen transport across the native lung (0.4±0.4 mL/kg/min). An increase in native lung oxygen transport (2.0±1.5 mL/kg/min) at low ventilator settings and high levels of extracorporeal support heralded recovery of the native lung and predicted weaning from ECMO. Measurement of oxygen consumption and carbon dioxide production permitted the energy expenditure to be calculated in these critically, ill neonates. The metabolic rates varied widely in each neonate over time and among neonates. (mean 57±11 kcal/kg/d, range 38 to 80 kcal/kg/d). This emphasizes the need to determine energy expenditure in order to guide nutritional support.

Original languageEnglish (US)
Pages (from-to)306-311
Number of pages6
JournalJournal of pediatric surgery
Volume23
Issue number4
DOIs
StatePublished - Apr 1988

Fingerprint

Extracorporeal Membrane Oxygenation
Gases
Lung
Oxygen
Carbon Dioxide
Energy Metabolism
Nutritional Support
Spirometry
Mechanical Ventilators
Weaning
Critical Illness
Oxygen Consumption
Membranes

All Science Journal Classification (ASJC) codes

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Cilley, Robert E. ; Wesley, John R. ; Zwischenberger, Joseph B. ; Bartlett, Robert H. / Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation. In: Journal of pediatric surgery. 1988 ; Vol. 23, No. 4. pp. 306-311.
@article{1263d5addc0c4f59aa9b6f321a5bfda0,
title = "Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation",
abstract = "Closed-circuit spirometry techniques were used to study gas exchange (oxygen and carbon dioxide transport) across the native lung and membrane lung in ten neonates treated with extracorporeal membrane oxygenation (ECMO). Initially there was negligible oxygen transport across the native lung (0.4±0.4 mL/kg/min). An increase in native lung oxygen transport (2.0±1.5 mL/kg/min) at low ventilator settings and high levels of extracorporeal support heralded recovery of the native lung and predicted weaning from ECMO. Measurement of oxygen consumption and carbon dioxide production permitted the energy expenditure to be calculated in these critically, ill neonates. The metabolic rates varied widely in each neonate over time and among neonates. (mean 57±11 kcal/kg/d, range 38 to 80 kcal/kg/d). This emphasizes the need to determine energy expenditure in order to guide nutritional support.",
author = "Cilley, {Robert E.} and Wesley, {John R.} and Zwischenberger, {Joseph B.} and Bartlett, {Robert H.}",
year = "1988",
month = "4",
doi = "10.1016/S0022-3468(88)80194-5",
language = "English (US)",
volume = "23",
pages = "306--311",
journal = "Journal of Pediatric Surgery",
issn = "0022-3468",
publisher = "W.B. Saunders Ltd",
number = "4",

}

Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation. / Cilley, Robert E.; Wesley, John R.; Zwischenberger, Joseph B.; Bartlett, Robert H.

In: Journal of pediatric surgery, Vol. 23, No. 4, 04.1988, p. 306-311.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gas exchange measurements in neonates treated with extracorporeal membrane oxygenation

AU - Cilley, Robert E.

AU - Wesley, John R.

AU - Zwischenberger, Joseph B.

AU - Bartlett, Robert H.

PY - 1988/4

Y1 - 1988/4

N2 - Closed-circuit spirometry techniques were used to study gas exchange (oxygen and carbon dioxide transport) across the native lung and membrane lung in ten neonates treated with extracorporeal membrane oxygenation (ECMO). Initially there was negligible oxygen transport across the native lung (0.4±0.4 mL/kg/min). An increase in native lung oxygen transport (2.0±1.5 mL/kg/min) at low ventilator settings and high levels of extracorporeal support heralded recovery of the native lung and predicted weaning from ECMO. Measurement of oxygen consumption and carbon dioxide production permitted the energy expenditure to be calculated in these critically, ill neonates. The metabolic rates varied widely in each neonate over time and among neonates. (mean 57±11 kcal/kg/d, range 38 to 80 kcal/kg/d). This emphasizes the need to determine energy expenditure in order to guide nutritional support.

AB - Closed-circuit spirometry techniques were used to study gas exchange (oxygen and carbon dioxide transport) across the native lung and membrane lung in ten neonates treated with extracorporeal membrane oxygenation (ECMO). Initially there was negligible oxygen transport across the native lung (0.4±0.4 mL/kg/min). An increase in native lung oxygen transport (2.0±1.5 mL/kg/min) at low ventilator settings and high levels of extracorporeal support heralded recovery of the native lung and predicted weaning from ECMO. Measurement of oxygen consumption and carbon dioxide production permitted the energy expenditure to be calculated in these critically, ill neonates. The metabolic rates varied widely in each neonate over time and among neonates. (mean 57±11 kcal/kg/d, range 38 to 80 kcal/kg/d). This emphasizes the need to determine energy expenditure in order to guide nutritional support.

UR - http://www.scopus.com/inward/record.url?scp=0023951470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023951470&partnerID=8YFLogxK

U2 - 10.1016/S0022-3468(88)80194-5

DO - 10.1016/S0022-3468(88)80194-5

M3 - Article

C2 - 3133459

AN - SCOPUS:0023951470

VL - 23

SP - 306

EP - 311

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

SN - 0022-3468

IS - 4

ER -