### Abstract

An axisymmetric single-path model (ASPM) for gas transport in the lower airways is developed and validated. A single airway path is represented by a series of straight tube segments interconnected by leaky transition regions that provide for flow loss at the airway bifurcations. The finite element method is used to solve the Navier-Stokes, continuity, and species convective-diffusion equations for the flow field and the species concentration distribution in the airways. The model is validated by comparing its predictions to the following experimental measurements: 1) dispersion coefficients for unsteady dispersion of an inhaled pulse of inert gas (benzene) along an airway path encompassing five generations in a scaled-up model of Weibel's symmetric airway geometry, and 2) mass transfer coefficients for steady inspiratory-directed flow of a reactive gas (formaldehyde) in both a single bifurcation and an airway path incorporating three generations of a symmetrically-branched physical model of the airways. For the latter problem, ASPM predictions are also compared with the results of three-dimensional finite element computations in the branched airway geometry. The ASPM results for the dispersion and mass transfer coefficients compare quantitatively well with both the experimental measurements and three-dimensional simulations.

Original language | English (US) |
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Title of host publication | 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings |

Pages | 8917 |

Number of pages | 1 |

State | Published - 2005 |

Event | 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States Duration: Oct 30 2005 → Nov 4 2005 |

### Other

Other | 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase |
---|---|

Country | United States |

City | Cincinnati, OH |

Period | 10/30/05 → 11/4/05 |

### Fingerprint

### All Science Journal Classification (ASJC) codes

- Engineering(all)

### Cite this

*05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings*(pp. 8917)

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*05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings.*pp. 8917, 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Cincinnati, OH, United States, 10/30/05.

**Gas transport in the conducting airways : An axisymmetric single-path model.** / Madasu, Srinath; Borhan, Ali; Ultman, James.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Gas transport in the conducting airways

T2 - An axisymmetric single-path model

AU - Madasu, Srinath

AU - Borhan, Ali

AU - Ultman, James

PY - 2005

Y1 - 2005

N2 - An axisymmetric single-path model (ASPM) for gas transport in the lower airways is developed and validated. A single airway path is represented by a series of straight tube segments interconnected by leaky transition regions that provide for flow loss at the airway bifurcations. The finite element method is used to solve the Navier-Stokes, continuity, and species convective-diffusion equations for the flow field and the species concentration distribution in the airways. The model is validated by comparing its predictions to the following experimental measurements: 1) dispersion coefficients for unsteady dispersion of an inhaled pulse of inert gas (benzene) along an airway path encompassing five generations in a scaled-up model of Weibel's symmetric airway geometry, and 2) mass transfer coefficients for steady inspiratory-directed flow of a reactive gas (formaldehyde) in both a single bifurcation and an airway path incorporating three generations of a symmetrically-branched physical model of the airways. For the latter problem, ASPM predictions are also compared with the results of three-dimensional finite element computations in the branched airway geometry. The ASPM results for the dispersion and mass transfer coefficients compare quantitatively well with both the experimental measurements and three-dimensional simulations.

AB - An axisymmetric single-path model (ASPM) for gas transport in the lower airways is developed and validated. A single airway path is represented by a series of straight tube segments interconnected by leaky transition regions that provide for flow loss at the airway bifurcations. The finite element method is used to solve the Navier-Stokes, continuity, and species convective-diffusion equations for the flow field and the species concentration distribution in the airways. The model is validated by comparing its predictions to the following experimental measurements: 1) dispersion coefficients for unsteady dispersion of an inhaled pulse of inert gas (benzene) along an airway path encompassing five generations in a scaled-up model of Weibel's symmetric airway geometry, and 2) mass transfer coefficients for steady inspiratory-directed flow of a reactive gas (formaldehyde) in both a single bifurcation and an airway path incorporating three generations of a symmetrically-branched physical model of the airways. For the latter problem, ASPM predictions are also compared with the results of three-dimensional finite element computations in the branched airway geometry. The ASPM results for the dispersion and mass transfer coefficients compare quantitatively well with both the experimental measurements and three-dimensional simulations.

UR - http://www.scopus.com/inward/record.url?scp=33645635081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645635081&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:33645635081

SP - 8917

BT - 05AIChE: 2005 AIChE Annual Meeting and Fall Showcase, Conference Proceedings

ER -