GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan, Shengyu Yang

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.

Original languageEnglish (US)
Pages (from-to)36971-36982
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
StatePublished - Dec 27 2013

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion'. Together they form a unique fingerprint.

Cite this