GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion

Jianwei Sun, Huifang He, Smitha Pillai, Yin Xiong, Sridevi Challa, Liyan Xu, Srikumar Chellappan, Shengyu Yang

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Background: Fascin is a pro-metastasis actin bundling protein overexpressed in basal-like breast cancer. Results: GATA3 abrogates TGFβ and Smad4-mediated fascin overexpression by abolishing the binding of Smad4 to fascin promoter. Conclusion: GATA3 is a novel suppressor of the canonical TGFβ-Smad signaling pathway. Significance: These findings provide mechanistic insight into how TGFβ-mediated invasion and metastasis are differentially regulated in different subgroups of breast cancer.

Original languageEnglish (US)
Pages (from-to)36971-36982
Number of pages12
JournalJournal of Biological Chemistry
Volume288
Issue number52
DOIs
StatePublished - Dec 27 2013

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GATA3 Transcription Factor
Transcription Factors
Cells
Breast Neoplasms
Neoplasm Metastasis
Actins
fascin
Podosomes
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Sun, Jianwei ; He, Huifang ; Pillai, Smitha ; Xiong, Yin ; Challa, Sridevi ; Xu, Liyan ; Chellappan, Srikumar ; Yang, Shengyu. / GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 52. pp. 36971-36982.
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GATA3 transcription factor abrogates Smad4 transcription factor-mediated fascin overexpression, invadopodium formation, and breast cancer cell invasion. / Sun, Jianwei; He, Huifang; Pillai, Smitha; Xiong, Yin; Challa, Sridevi; Xu, Liyan; Chellappan, Srikumar; Yang, Shengyu.

In: Journal of Biological Chemistry, Vol. 288, No. 52, 27.12.2013, p. 36971-36982.

Research output: Contribution to journalArticle

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AU - Challa, Sridevi

AU - Xu, Liyan

AU - Chellappan, Srikumar

AU - Yang, Shengyu

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