TY - JOUR
T1 - GDF-15
T2 - Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme
AU - Hasanpour Segherlou, Zahra
AU - Nouri-Vaskeh, Masoud
AU - Noroozi Guilandehi, Sama
AU - Baghbanzadeh, Amir
AU - Zand, Ramin
AU - Baradaran, Behzad
AU - Zarei, Mohammad
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/8
Y1 - 2021/8
N2 - Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF-15) belongs to transforming growth factor-β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF-15 to develop and progress cancer is complicated and remains unclear. GDF-15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF-15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF-15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.
AB - Glioblastoma multiforme (GBM) is the commonest primary malignant brain tumor and has a remarkably weak prognosis. According to the aggressive form of GBM, understanding the accurate molecular mechanism associated with GBM pathogenesis is essential. Growth differentiation factor 15 (GDF-15) belongs to transforming growth factor-β superfamily with important roles to control biological processes. It affects cancer growth and progression, drug resistance, and metastasis. It also can promote stemness in many cancers, and also can stress reactions control, bone generation, hematopoietic growth, adipose tissue performance, and body growth, and contributes to cardiovascular disorders. The role GDF-15 to develop and progress cancer is complicated and remains unclear. GDF-15 possesses tumor suppressor properties, as well as an oncogenic effect. GDF-15 antitumorigenic and protumorigenic impacts on tumor development are linked to the cancer type and stage. However, the GDF-15 signaling and mechanism have not yet been completely identified because of no recognized cognate receptor.
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U2 - 10.1002/jcp.30289
DO - 10.1002/jcp.30289
M3 - Review article
C2 - 33580506
AN - SCOPUS:85100858443
SN - 0021-9541
VL - 236
SP - 5564
EP - 5581
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 8
ER -
