Gender and ethnic differences in arterial compliance in patients with intermittent claudication

Andrew Gardner, Polly S. Montgomery, Steve M. Blevins, Donald E. Parker

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Objective: To assess the gender and ethnic differences in arterial compliance in patients with intermittent claudication. Methods: A total of 114 patients participated, including 38 Caucasian men, 32 Caucasian women, 16 African American men, and 28 African American women. Patients were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), age, weight, body mass index, ankle-brachial index (ABI), smoking status, and metabolic syndrome components. Results: Group differences were found for LAEI (P = .042), SAEI (P = .019), body mass index (P = .020), prevalence of elevated fasting glucose (P = .001), and prevalence of abdominal obesity (P = .025). Significant covariates for LAEI included age (P = .0002) and elevated triglycerides (P = .0719). LAEI (units = 10 mL × mm Hg) adjusted for age and triglycerides was 39% lower (P = .0005) in African Americans (11.4 ± .90; mean ± SE) than in Caucasians (15.8 ± 0.72), whereas no significant difference (P = .7904) existed between men (13.8 ± 0.81) and women (13.5 ± 0.79). Significant covariates for SAEI included age (P = .0001), abdominal obesity (P = .0030), and elevated blood pressure (P = .0067). SAEI (units = 100 mL × mm Hg) adjusted for age, abdominal obesity, and elevated blood pressure was 32% lower (P = .0007) in African-Americans (2.8 ± 0.3) than in Caucasians 4.1 ± 0.2), and was 18% lower (P = .0442) in women (3.1 ± 0.2) than in men (3.8 ± 0.2). Conclusion: African American patients with intermittent claudication have more impaired macrovascular and microvascular function than Caucasian patients, and women have more impaired microvascular function than men. These ethnic and gender differences in arterial compliance are evident even though ABI was similar among groups, suggesting that arterial compliance provides unique information to quantify vascular impairment in patients with intermittent claudication.

Original languageEnglish (US)
Pages (from-to)610-615
Number of pages6
JournalJournal of Vascular Surgery
Volume51
Issue number3
DOIs
StatePublished - Mar 1 2010

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Intermittent Claudication
Elasticity
Patient Compliance
Arteries
African Americans
Abdominal Obesity
Ankle Brachial Index
Compliance
Triglycerides
Body Mass Index
Blood Pressure
Blood Vessels
Fasting
Smoking
Weights and Measures
Glucose

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Gardner, Andrew ; Montgomery, Polly S. ; Blevins, Steve M. ; Parker, Donald E. / Gender and ethnic differences in arterial compliance in patients with intermittent claudication. In: Journal of Vascular Surgery. 2010 ; Vol. 51, No. 3. pp. 610-615.
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abstract = "Objective: To assess the gender and ethnic differences in arterial compliance in patients with intermittent claudication. Methods: A total of 114 patients participated, including 38 Caucasian men, 32 Caucasian women, 16 African American men, and 28 African American women. Patients were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), age, weight, body mass index, ankle-brachial index (ABI), smoking status, and metabolic syndrome components. Results: Group differences were found for LAEI (P = .042), SAEI (P = .019), body mass index (P = .020), prevalence of elevated fasting glucose (P = .001), and prevalence of abdominal obesity (P = .025). Significant covariates for LAEI included age (P = .0002) and elevated triglycerides (P = .0719). LAEI (units = 10 mL × mm Hg) adjusted for age and triglycerides was 39{\%} lower (P = .0005) in African Americans (11.4 ± .90; mean ± SE) than in Caucasians (15.8 ± 0.72), whereas no significant difference (P = .7904) existed between men (13.8 ± 0.81) and women (13.5 ± 0.79). Significant covariates for SAEI included age (P = .0001), abdominal obesity (P = .0030), and elevated blood pressure (P = .0067). SAEI (units = 100 mL × mm Hg) adjusted for age, abdominal obesity, and elevated blood pressure was 32{\%} lower (P = .0007) in African-Americans (2.8 ± 0.3) than in Caucasians 4.1 ± 0.2), and was 18{\%} lower (P = .0442) in women (3.1 ± 0.2) than in men (3.8 ± 0.2). Conclusion: African American patients with intermittent claudication have more impaired macrovascular and microvascular function than Caucasian patients, and women have more impaired microvascular function than men. These ethnic and gender differences in arterial compliance are evident even though ABI was similar among groups, suggesting that arterial compliance provides unique information to quantify vascular impairment in patients with intermittent claudication.",
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Gender and ethnic differences in arterial compliance in patients with intermittent claudication. / Gardner, Andrew; Montgomery, Polly S.; Blevins, Steve M.; Parker, Donald E.

In: Journal of Vascular Surgery, Vol. 51, No. 3, 01.03.2010, p. 610-615.

Research output: Contribution to journalArticle

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T1 - Gender and ethnic differences in arterial compliance in patients with intermittent claudication

AU - Gardner, Andrew

AU - Montgomery, Polly S.

AU - Blevins, Steve M.

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N2 - Objective: To assess the gender and ethnic differences in arterial compliance in patients with intermittent claudication. Methods: A total of 114 patients participated, including 38 Caucasian men, 32 Caucasian women, 16 African American men, and 28 African American women. Patients were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), age, weight, body mass index, ankle-brachial index (ABI), smoking status, and metabolic syndrome components. Results: Group differences were found for LAEI (P = .042), SAEI (P = .019), body mass index (P = .020), prevalence of elevated fasting glucose (P = .001), and prevalence of abdominal obesity (P = .025). Significant covariates for LAEI included age (P = .0002) and elevated triglycerides (P = .0719). LAEI (units = 10 mL × mm Hg) adjusted for age and triglycerides was 39% lower (P = .0005) in African Americans (11.4 ± .90; mean ± SE) than in Caucasians (15.8 ± 0.72), whereas no significant difference (P = .7904) existed between men (13.8 ± 0.81) and women (13.5 ± 0.79). Significant covariates for SAEI included age (P = .0001), abdominal obesity (P = .0030), and elevated blood pressure (P = .0067). SAEI (units = 100 mL × mm Hg) adjusted for age, abdominal obesity, and elevated blood pressure was 32% lower (P = .0007) in African-Americans (2.8 ± 0.3) than in Caucasians 4.1 ± 0.2), and was 18% lower (P = .0442) in women (3.1 ± 0.2) than in men (3.8 ± 0.2). Conclusion: African American patients with intermittent claudication have more impaired macrovascular and microvascular function than Caucasian patients, and women have more impaired microvascular function than men. These ethnic and gender differences in arterial compliance are evident even though ABI was similar among groups, suggesting that arterial compliance provides unique information to quantify vascular impairment in patients with intermittent claudication.

AB - Objective: To assess the gender and ethnic differences in arterial compliance in patients with intermittent claudication. Methods: A total of 114 patients participated, including 38 Caucasian men, 32 Caucasian women, 16 African American men, and 28 African American women. Patients were assessed on large artery elasticity index (LAEI), small artery elasticity index (SAEI), age, weight, body mass index, ankle-brachial index (ABI), smoking status, and metabolic syndrome components. Results: Group differences were found for LAEI (P = .042), SAEI (P = .019), body mass index (P = .020), prevalence of elevated fasting glucose (P = .001), and prevalence of abdominal obesity (P = .025). Significant covariates for LAEI included age (P = .0002) and elevated triglycerides (P = .0719). LAEI (units = 10 mL × mm Hg) adjusted for age and triglycerides was 39% lower (P = .0005) in African Americans (11.4 ± .90; mean ± SE) than in Caucasians (15.8 ± 0.72), whereas no significant difference (P = .7904) existed between men (13.8 ± 0.81) and women (13.5 ± 0.79). Significant covariates for SAEI included age (P = .0001), abdominal obesity (P = .0030), and elevated blood pressure (P = .0067). SAEI (units = 100 mL × mm Hg) adjusted for age, abdominal obesity, and elevated blood pressure was 32% lower (P = .0007) in African-Americans (2.8 ± 0.3) than in Caucasians 4.1 ± 0.2), and was 18% lower (P = .0442) in women (3.1 ± 0.2) than in men (3.8 ± 0.2). Conclusion: African American patients with intermittent claudication have more impaired macrovascular and microvascular function than Caucasian patients, and women have more impaired microvascular function than men. These ethnic and gender differences in arterial compliance are evident even though ABI was similar among groups, suggesting that arterial compliance provides unique information to quantify vascular impairment in patients with intermittent claudication.

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