Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury

Ashraf S. Gorgey, Gary J. Farkas, David R. Dolbow, Refka E. Khalil, David Gater

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Increase in visceral adipose tissue (VAT) is an independent risk for mortality and other health-related comorbidities. Objective: To examine the gender differences in VAT and subcutaneous adipose tissue (SAT) cross-sectional areas (CSA) between men and women with chronic spinal cord injury (SCI). The differences in the distribution of central adiposity were used to determine the association of VAT and SAT to metabolic dysfunction after SCI. Design: Cross-sectional design. Setting: Hospital-based study. Participants: Sixteen individuals (8 men and 8 women) with motor complete SCI were matched based on age, time since injury, and level of injury. Methods: Anthropometrics, dual x-ray absorptiometry (DXA), and magnetic resonance imaging were captured to measure lean mass, fat mass (FM), percentage FM, VAT, and SAT CSAs. Basal metabolic rate was measured, and intravenous glucose tolerance test and lipid panel were performed. Main Outcome Measurements: VAT, SAT, and metabolic profile. Results: SAT CSA was 1.6 -1.75 times greater in the upper and lower trunks in women compared to men with SCI (P <.05). VAT CSA was 1.8-2.6 times greater in the upper and lower trunks in men compared to women with SCI (P <.05). VAT adjusted to body weight was greater in men compared to women with SCI. High-density lipoprotein cholesterol (HDL-C) was positively related to SAT and negatively related to VAT. Glucose effectiveness was negatively related to lower trunk SAT (r = −0.60, P =.02). HDL-C ratio and triglycerides were positively related to upper VAT, lower VAT, and VAT:SAT ratio. Conclusion: Magnetic resonance imaging demonstrated that there is a gender dimorphism in central adiposity in persons with chronic SCI. This gender dimorphism in central adipose tissue distribution may explain the higher prevalence of metabolic dysfunction in men with SCI, especially, the decrease in the HDL-C profile. Level of Evidence: IV

Original languageEnglish (US)
Pages (from-to)338-348
Number of pages11
JournalPM and R
Volume10
Issue number4
DOIs
StatePublished - Apr 1 2018

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Intra-Abdominal Fat
Adiposity
Spinal Cord Injuries
Subcutaneous Fat
HDL Cholesterol
Fats
Magnetic Resonance Imaging
Basal Metabolism
Metabolome
Wounds and Injuries
Tissue Distribution
Glucose Tolerance Test
Adipose Tissue
Comorbidity
Body Weight
X-Rays
Lipids
Glucose

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Neurology
  • Clinical Neurology

Cite this

Gorgey, A. S., Farkas, G. J., Dolbow, D. R., Khalil, R. E., & Gater, D. (2018). Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury. PM and R, 10(4), 338-348. https://doi.org/10.1016/j.pmrj.2017.08.436
Gorgey, Ashraf S. ; Farkas, Gary J. ; Dolbow, David R. ; Khalil, Refka E. ; Gater, David. / Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury. In: PM and R. 2018 ; Vol. 10, No. 4. pp. 338-348.
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Gorgey, AS, Farkas, GJ, Dolbow, DR, Khalil, RE & Gater, D 2018, 'Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury', PM and R, vol. 10, no. 4, pp. 338-348. https://doi.org/10.1016/j.pmrj.2017.08.436

Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury. / Gorgey, Ashraf S.; Farkas, Gary J.; Dolbow, David R.; Khalil, Refka E.; Gater, David.

In: PM and R, Vol. 10, No. 4, 01.04.2018, p. 338-348.

Research output: Contribution to journalArticle

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T1 - Gender Dimorphism in Central Adiposity May Explain Metabolic Dysfunction After Spinal Cord Injury

AU - Gorgey, Ashraf S.

AU - Farkas, Gary J.

AU - Dolbow, David R.

AU - Khalil, Refka E.

AU - Gater, David

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N2 - Background: Increase in visceral adipose tissue (VAT) is an independent risk for mortality and other health-related comorbidities. Objective: To examine the gender differences in VAT and subcutaneous adipose tissue (SAT) cross-sectional areas (CSA) between men and women with chronic spinal cord injury (SCI). The differences in the distribution of central adiposity were used to determine the association of VAT and SAT to metabolic dysfunction after SCI. Design: Cross-sectional design. Setting: Hospital-based study. Participants: Sixteen individuals (8 men and 8 women) with motor complete SCI were matched based on age, time since injury, and level of injury. Methods: Anthropometrics, dual x-ray absorptiometry (DXA), and magnetic resonance imaging were captured to measure lean mass, fat mass (FM), percentage FM, VAT, and SAT CSAs. Basal metabolic rate was measured, and intravenous glucose tolerance test and lipid panel were performed. Main Outcome Measurements: VAT, SAT, and metabolic profile. Results: SAT CSA was 1.6 -1.75 times greater in the upper and lower trunks in women compared to men with SCI (P <.05). VAT CSA was 1.8-2.6 times greater in the upper and lower trunks in men compared to women with SCI (P <.05). VAT adjusted to body weight was greater in men compared to women with SCI. High-density lipoprotein cholesterol (HDL-C) was positively related to SAT and negatively related to VAT. Glucose effectiveness was negatively related to lower trunk SAT (r = −0.60, P =.02). HDL-C ratio and triglycerides were positively related to upper VAT, lower VAT, and VAT:SAT ratio. Conclusion: Magnetic resonance imaging demonstrated that there is a gender dimorphism in central adiposity in persons with chronic SCI. This gender dimorphism in central adipose tissue distribution may explain the higher prevalence of metabolic dysfunction in men with SCI, especially, the decrease in the HDL-C profile. Level of Evidence: IV

AB - Background: Increase in visceral adipose tissue (VAT) is an independent risk for mortality and other health-related comorbidities. Objective: To examine the gender differences in VAT and subcutaneous adipose tissue (SAT) cross-sectional areas (CSA) between men and women with chronic spinal cord injury (SCI). The differences in the distribution of central adiposity were used to determine the association of VAT and SAT to metabolic dysfunction after SCI. Design: Cross-sectional design. Setting: Hospital-based study. Participants: Sixteen individuals (8 men and 8 women) with motor complete SCI were matched based on age, time since injury, and level of injury. Methods: Anthropometrics, dual x-ray absorptiometry (DXA), and magnetic resonance imaging were captured to measure lean mass, fat mass (FM), percentage FM, VAT, and SAT CSAs. Basal metabolic rate was measured, and intravenous glucose tolerance test and lipid panel were performed. Main Outcome Measurements: VAT, SAT, and metabolic profile. Results: SAT CSA was 1.6 -1.75 times greater in the upper and lower trunks in women compared to men with SCI (P <.05). VAT CSA was 1.8-2.6 times greater in the upper and lower trunks in men compared to women with SCI (P <.05). VAT adjusted to body weight was greater in men compared to women with SCI. High-density lipoprotein cholesterol (HDL-C) was positively related to SAT and negatively related to VAT. Glucose effectiveness was negatively related to lower trunk SAT (r = −0.60, P =.02). HDL-C ratio and triglycerides were positively related to upper VAT, lower VAT, and VAT:SAT ratio. Conclusion: Magnetic resonance imaging demonstrated that there is a gender dimorphism in central adiposity in persons with chronic SCI. This gender dimorphism in central adipose tissue distribution may explain the higher prevalence of metabolic dysfunction in men with SCI, especially, the decrease in the HDL-C profile. Level of Evidence: IV

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