Gene-environment contributions to the development of infant vagal reactivity: The interaction of dopamine and maternal sensitivity

Cathi Propper, Ginger A. Moore, W. Roger Mills-Koonce, Carolyn Tucker Halpern, Ashley L. Hill-Soderlund, Susan D. Calkins, Mary Anna Carbone, Martha Cox

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

This study investigated dopamine receptor genes (DRD2 and DRD4) and maternal sensitivity as predictors of infant respiratory sinus arrhythmia (RSA) and RSA reactivity, purported indices of vagal tone and vagal regulation, in a challenge task at 3, 6, and 12 months in 173 infant-mother dyads. Hierarchical linear modeling (HLM) revealed that at 3 and 6 months, RSA withdrawal in response to maternal separation was greater (suggesting expected physiological regulation) in infants without the DRD2 risk allele than those with the risk allele. At 12 months, infants with the risk allele who were also exposed to maternal sensitivity showed levels of RSA withdrawal comparable to infants who were not at genetic risk. Findings demonstrate the importance of developmental analysis of gene-environment interaction.

Original languageEnglish (US)
Pages (from-to)1377-1394
Number of pages18
JournalChild development
Volume79
Issue number5
DOIs
StatePublished - Sep 1 2008

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Education
  • Developmental and Educational Psychology

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    Propper, C., Moore, G. A., Mills-Koonce, W. R., Halpern, C. T., Hill-Soderlund, A. L., Calkins, S. D., Carbone, M. A., & Cox, M. (2008). Gene-environment contributions to the development of infant vagal reactivity: The interaction of dopamine and maternal sensitivity. Child development, 79(5), 1377-1394. https://doi.org/10.1111/j.1467-8624.2008.01194.x