Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.)

R. H. Ffrench-Constant, R. T. Roush

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen). The gene was further mapped by the use of chromosomal deficiencies to a single letter sub-region, 66F, on the polytene chromosome. The cross-resistance spectrum of a backcrossed strain lacking elevated mixed function oxidase activity, a common resistance mechanism, was examined. Levels of resistance similar to those found in other insects were found to dieldrin, aldrin, endrin, lindane, and picrotoxinin. Strong similarity of this single major gene with that found in other cyclodiene resistant insects is suggested by its cross-resistance spectrum and chromosomal location, via homology with other Diptera. The significance of major genes in insecticide resistance is discussed.

Original languageEnglish (US)
Pages (from-to)17-21
Number of pages5
JournalGenetical research
Volume57
Issue number1
DOIs
StatePublished - Feb 1991

Fingerprint

Chromosome Mapping
Insecticides
Drosophila melanogaster
Dieldrin
Genes
Insects
Endrin
Aldrin
Insecticide Resistance
Polytene Chromosomes
Lindane
Mixed Function Oxygenases
Diptera
Chromosomes

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

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abstract = "Resistance to the cyclodiene insecticide dieldrin maps to a single gene (Rdl) on the left arm of chromosome III in Drosophila melanogaster (Meigen). The gene was further mapped by the use of chromosomal deficiencies to a single letter sub-region, 66F, on the polytene chromosome. The cross-resistance spectrum of a backcrossed strain lacking elevated mixed function oxidase activity, a common resistance mechanism, was examined. Levels of resistance similar to those found in other insects were found to dieldrin, aldrin, endrin, lindane, and picrotoxinin. Strong similarity of this single major gene with that found in other cyclodiene resistant insects is suggested by its cross-resistance spectrum and chromosomal location, via homology with other Diptera. The significance of major genes in insecticide resistance is discussed.",
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Gene mapping and cross-resistance in cyclodiene insecticide-resistant Drosophila melanogaster (Mg.). / Ffrench-Constant, R. H.; Roush, R. T.

In: Genetical research, Vol. 57, No. 1, 02.1991, p. 17-21.

Research output: Contribution to journalArticle

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