Gene therapy

Chemoprotection, immunoenhancement, and modification of tumor cells

A. B. Deisseroth, J. J. Kavanagh, E. G. Hanania, S. Fu, S. M. Kornblau, E. Estey, M. Talpaz, H. M. Kantarjian, David Claxton, C. L. Reading, D. A. Dixon, R. W. Anderson, G. Lopez-Berestein, F. A. Holmes, C. J. Logothetis, M. Andreeff, W. Benedict

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalCancer Bulletin
Volume45
Issue number2
StatePublished - Jun 2 1993

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Genetic Therapy
Retroviridae
Drug Resistance
Bone Marrow Cells
Immune System
Neoplasms
Stem Cells
Safety
Drug Therapy
Therapeutics
Genes
Direction compound

All Science Journal Classification (ASJC) codes

  • Cancer Research

Cite this

Deisseroth, A. B., Kavanagh, J. J., Hanania, E. G., Fu, S., Kornblau, S. M., Estey, E., ... Benedict, W. (1993). Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells. Cancer Bulletin, 45(2), 139-145.
Deisseroth, A. B. ; Kavanagh, J. J. ; Hanania, E. G. ; Fu, S. ; Kornblau, S. M. ; Estey, E. ; Talpaz, M. ; Kantarjian, H. M. ; Claxton, David ; Reading, C. L. ; Dixon, D. A. ; Anderson, R. W. ; Lopez-Berestein, G. ; Holmes, F. A. ; Logothetis, C. J. ; Andreeff, M. ; Benedict, W. / Gene therapy : Chemoprotection, immunoenhancement, and modification of tumor cells. In: Cancer Bulletin. 1993 ; Vol. 45, No. 2. pp. 139-145.
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abstract = "Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.",
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Deisseroth, AB, Kavanagh, JJ, Hanania, EG, Fu, S, Kornblau, SM, Estey, E, Talpaz, M, Kantarjian, HM, Claxton, D, Reading, CL, Dixon, DA, Anderson, RW, Lopez-Berestein, G, Holmes, FA, Logothetis, CJ, Andreeff, M & Benedict, W 1993, 'Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells', Cancer Bulletin, vol. 45, no. 2, pp. 139-145.

Gene therapy : Chemoprotection, immunoenhancement, and modification of tumor cells. / Deisseroth, A. B.; Kavanagh, J. J.; Hanania, E. G.; Fu, S.; Kornblau, S. M.; Estey, E.; Talpaz, M.; Kantarjian, H. M.; Claxton, David; Reading, C. L.; Dixon, D. A.; Anderson, R. W.; Lopez-Berestein, G.; Holmes, F. A.; Logothetis, C. J.; Andreeff, M.; Benedict, W.

In: Cancer Bulletin, Vol. 45, No. 2, 02.06.1993, p. 139-145.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Gene therapy

T2 - Chemoprotection, immunoenhancement, and modification of tumor cells

AU - Deisseroth, A. B.

AU - Kavanagh, J. J.

AU - Hanania, E. G.

AU - Fu, S.

AU - Kornblau, S. M.

AU - Estey, E.

AU - Talpaz, M.

AU - Kantarjian, H. M.

AU - Claxton, David

AU - Reading, C. L.

AU - Dixon, D. A.

AU - Anderson, R. W.

AU - Lopez-Berestein, G.

AU - Holmes, F. A.

AU - Logothetis, C. J.

AU - Andreeff, M.

AU - Benedict, W.

PY - 1993/6/2

Y1 - 1993/6/2

N2 - Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

AB - Concepts for studies designed to introduce safety-modified retroviruses into repopulating cells of the bone marrow are reviewed here. These studies will set the stage for chemotherapy protection programs that involve insertion of drug resistance genes into the early progenitor cells of the hematopoitic system. We also describe studies under way to modify tumor cells, so as to provoke a more dramatic and decisive cytotoxic response from the effector cells of the immune system. These are new directions in therapy that may enhance and complement standard programs of therapy and lead to the control of neoplastic disease currently uncontrolled by existing modalities.

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M3 - Review article

VL - 45

SP - 139

EP - 145

JO - Cancer Bulletin

JF - Cancer Bulletin

SN - 0008-5448

IS - 2

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Deisseroth AB, Kavanagh JJ, Hanania EG, Fu S, Kornblau SM, Estey E et al. Gene therapy: Chemoprotection, immunoenhancement, and modification of tumor cells. Cancer Bulletin. 1993 Jun 2;45(2):139-145.