Gene therapy utilizing drug resistance genes

A review

Debabrata Banerjee, Shi Cheng Zhao, Ming‐Xia ‐X Li, Barry I. Schweitzer, Shin Mineishi, Joseph R. Bertino

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalSTEM CELLS
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1994

Fingerprint

Drug Resistance
Genetic Therapy
Bone Marrow
Genes
Animal Models
Technology
Pharmaceutical Preparations
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

Cite this

Banerjee, D., Zhao, S. C., Li, MX. X., Schweitzer, B. I., Mineishi, S., & Bertino, J. R. (1994). Gene therapy utilizing drug resistance genes: A review. STEM CELLS, 12(4), 378-385. https://doi.org/10.1002/stem.5530120404
Banerjee, Debabrata ; Zhao, Shi Cheng ; Li, Ming‐Xia ‐X ; Schweitzer, Barry I. ; Mineishi, Shin ; Bertino, Joseph R. / Gene therapy utilizing drug resistance genes : A review. In: STEM CELLS. 1994 ; Vol. 12, No. 4. pp. 378-385.
@article{5e01ed5fe444425587f92e6cbf09332d,
title = "Gene therapy utilizing drug resistance genes: A review",
abstract = "The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.",
author = "Debabrata Banerjee and Zhao, {Shi Cheng} and Li, {Ming‐Xia ‐X} and Schweitzer, {Barry I.} and Shin Mineishi and Bertino, {Joseph R.}",
year = "1994",
month = "1",
day = "1",
doi = "10.1002/stem.5530120404",
language = "English (US)",
volume = "12",
pages = "378--385",
journal = "Stem Cells",
issn = "1066-5099",
publisher = "AlphaMed Press",
number = "4",

}

Banerjee, D, Zhao, SC, Li, MXX, Schweitzer, BI, Mineishi, S & Bertino, JR 1994, 'Gene therapy utilizing drug resistance genes: A review', STEM CELLS, vol. 12, no. 4, pp. 378-385. https://doi.org/10.1002/stem.5530120404

Gene therapy utilizing drug resistance genes : A review. / Banerjee, Debabrata; Zhao, Shi Cheng; Li, Ming‐Xia ‐X; Schweitzer, Barry I.; Mineishi, Shin; Bertino, Joseph R.

In: STEM CELLS, Vol. 12, No. 4, 01.01.1994, p. 378-385.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gene therapy utilizing drug resistance genes

T2 - A review

AU - Banerjee, Debabrata

AU - Zhao, Shi Cheng

AU - Li, Ming‐Xia ‐X

AU - Schweitzer, Barry I.

AU - Mineishi, Shin

AU - Bertino, Joseph R.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

AB - The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

UR - http://www.scopus.com/inward/record.url?scp=0028023141&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028023141&partnerID=8YFLogxK

U2 - 10.1002/stem.5530120404

DO - 10.1002/stem.5530120404

M3 - Article

VL - 12

SP - 378

EP - 385

JO - Stem Cells

JF - Stem Cells

SN - 1066-5099

IS - 4

ER -

Banerjee D, Zhao SC, Li MXX, Schweitzer BI, Mineishi S, Bertino JR. Gene therapy utilizing drug resistance genes: A review. STEM CELLS. 1994 Jan 1;12(4):378-385. https://doi.org/10.1002/stem.5530120404