Gene therapy utilizing drug resistance genes: A review

Debabrata Banerjee, Shi Cheng Zhao, Ming‐Xia ‐X Li, Barry I. Schweitzer, Shin Mineishi, Joseph R. Bertino

Research output: Contribution to journalArticlepeer-review

31 Scopus citations

Abstract

The generation of drug resistant bone marrow may facilitate the development of aggressive chemotherapeutic regimens that might otherwise be lethal due to marrow toxicity. With the availability of technology that permits in vitro manipulation of human marrow and peripheral blood stem cells, it is now possible to introduce genes that confer drug resistance to these hematopoietic progenitors. Animal models and in vitro work with human progenitors using drug resistance genes are reviewed.

Original languageEnglish (US)
Pages (from-to)378-385
Number of pages8
JournalSTEM CELLS
Volume12
Issue number4
DOIs
StatePublished - 1994

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Developmental Biology
  • Cell Biology

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