General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting β-agonists

Research output: Contribution to journalReview article

14 Citations (Scopus)

Abstract

A systematic review attempts to summarize the scientific evidence related to treatment, causation, diagnosis, or prognosis of a specific disease. Meta-analysis refers to that portion of the systematic review that involves the statistical analysis. This perspective describes the appropriate steps in a systematic review and meta-analysis and critiques the recent systematic review on the effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths. The authors of this systematic review identified 19 relevant studies and applied most of the methodological steps appropriately, although there is some concern about publication bias. The authors uncovered statistically significantly increased risk for long-acting β-agonists compared with placebo with respect to severe asthma exacerbations, life-threatening asthma exacerbations, and asthma-related deaths. Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80% of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths.

Original languageEnglish (US)
Pages (from-to)303-306
Number of pages4
JournalJournal of Allergy and Clinical Immunology
Volume119
Issue number2
DOIs
StatePublished - Feb 1 2007

Fingerprint

Meta-Analysis
Asthma
Publication Bias
Causality
Placebos
Research

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

@article{03286a4d979949718d7a44a69494af1f,
title = "General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting β-agonists",
abstract = "A systematic review attempts to summarize the scientific evidence related to treatment, causation, diagnosis, or prognosis of a specific disease. Meta-analysis refers to that portion of the systematic review that involves the statistical analysis. This perspective describes the appropriate steps in a systematic review and meta-analysis and critiques the recent systematic review on the effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths. The authors of this systematic review identified 19 relevant studies and applied most of the methodological steps appropriately, although there is some concern about publication bias. The authors uncovered statistically significantly increased risk for long-acting β-agonists compared with placebo with respect to severe asthma exacerbations, life-threatening asthma exacerbations, and asthma-related deaths. Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80{\%} of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths.",
author = "Vernon Chinchilli",
year = "2007",
month = "2",
day = "1",
doi = "10.1016/j.jaci.2006.11.632",
language = "English (US)",
volume = "119",
pages = "303--306",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting β-agonists

AU - Chinchilli, Vernon

PY - 2007/2/1

Y1 - 2007/2/1

N2 - A systematic review attempts to summarize the scientific evidence related to treatment, causation, diagnosis, or prognosis of a specific disease. Meta-analysis refers to that portion of the systematic review that involves the statistical analysis. This perspective describes the appropriate steps in a systematic review and meta-analysis and critiques the recent systematic review on the effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths. The authors of this systematic review identified 19 relevant studies and applied most of the methodological steps appropriately, although there is some concern about publication bias. The authors uncovered statistically significantly increased risk for long-acting β-agonists compared with placebo with respect to severe asthma exacerbations, life-threatening asthma exacerbations, and asthma-related deaths. Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80% of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths.

AB - A systematic review attempts to summarize the scientific evidence related to treatment, causation, diagnosis, or prognosis of a specific disease. Meta-analysis refers to that portion of the systematic review that involves the statistical analysis. This perspective describes the appropriate steps in a systematic review and meta-analysis and critiques the recent systematic review on the effect of long-acting β-agonists on severe asthma exacerbations and asthma-related deaths. The authors of this systematic review identified 19 relevant studies and applied most of the methodological steps appropriately, although there is some concern about publication bias. The authors uncovered statistically significantly increased risk for long-acting β-agonists compared with placebo with respect to severe asthma exacerbations, life-threatening asthma exacerbations, and asthma-related deaths. Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80% of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths.

UR - http://www.scopus.com/inward/record.url?scp=33846827189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846827189&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2006.11.632

DO - 10.1016/j.jaci.2006.11.632

M3 - Review article

C2 - 17291850

AN - SCOPUS:33846827189

VL - 119

SP - 303

EP - 306

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 2

ER -