Generation of antigen-specific T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy

Fengyang Lei, Rizwanul Haque, Xiaofang Xiong, Jianxun Song

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Conquering cancer, one of the leading human health problems, is a major task for both basic and clinical scientists. With the understanding of recently developed cancer immunotherapy, in particular the cytotoxic T lymphocyte (CTL)-mediated immunotherapy, T cell development as well as the applications of stem cell technologies, an individualized cancer immunotherapy could be promisingly designed by avoiding several main obstacles in obtaining a large number of autologous and highlyreactive tumor-specific CTLs. Through induced pluripotent stem (iPS) cell technologies, tumor-specific CTLs could be generated from a piece of skin or blood from the individual cancer patient, following genetic modification as well as a directed differentiation. This novel approach could potentially further expand the weaponry to battle cancer.

Original languageEnglish (US)
Title of host publicationStem Cells and Cancer Stem Cells, Volume 10
Subtitle of host publicationTherapeutic Applications in Disease and Injury
PublisherSpringer Netherlands
Pages105-121
Number of pages17
ISBN (Electronic)9789400762626
ISBN (Print)9789400762619
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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  • Cite this

    Lei, F., Haque, R., Xiong, X., & Song, J. (2013). Generation of antigen-specific T lymphocytes from induced pluripotent stem cells for adoptive immunotherapy. In Stem Cells and Cancer Stem Cells, Volume 10: Therapeutic Applications in Disease and Injury (pp. 105-121). Springer Netherlands. https://doi.org/10.1007/978-94-007-6262-6_10