Genetic adaptation to historical pathogen burdens

Johannes W. Fedderke, Robert E. Klitgaard, Valerio Napolioni

Research output: Contribution to journalArticle

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Abstract

Historical pathogen burdens are examined as possible triggers for genetic adaptation. Evidence of adaptation emerges for the acid phosphatase locus 1 (ACP1), interleukin-6 (IL6), interleukin-10 (IL10 ), human leukocyte antigen (HLA) polymorphisms, along with a measure of heterozygosity over 783 alleles. Results are robust to controlling for the physical and historical environment humans faced, and to endogeneity of the historical pathogen burden measure. The present study represents a proof-of-concept which may pave the way to the analysis of future aggregate measures coming from whole-genome sequencing/genotyping data.

Original languageEnglish (US)
Pages (from-to)299-307
Number of pages9
JournalInfection, Genetics and Evolution
Volume54
DOIs
Publication statusPublished - Oct 2017

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

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